文献类型：期刊文献

中文题名：毛蚶糖胺聚糖的理化性质及其对小鼠免疫脏器影响的初步研究

英文题名：Preliminary Study on Physicochemical Property of Glycosaminoglycan from Area Suhcrenate Lisehke and its Effects on Immune Organs of Mice

作者：胡雪琼[1];吴红棉[1];林志明[1];范秀萍[1]

机构：[1]广东海洋大学食品科技学院,广东湛江524025

年份：2008

卷号：24

期号：8

起止页码：763

中文期刊名：现代食品科技

外文期刊名：Modern Food Science and Technology

收录：CSTPCD、、Scopus

基金：广东海洋大学团队项目2007-3

语种：中文

中文关键词：毛蚶;糖胺聚糖;理化性质;胸腺指数;脾指数

外文关键词：Area Suhcrenate Lisehk; glycosaminoglycan; physico-chemical property; thymus index; spleen index

中文摘要：以毛蚶全脏器为原料,分离提取糖胺聚糖(SSG),经分级纯化得到三个主要级分,对其理化性质及其对小鼠免疫脏器的影响进行初步探讨。成分分析表明:三个主要级分组成均主要以氨基己糖为主,含有己糖醛酸、硫酸基;红外光谱显示纯化毛蚶SSG的三个级分均含有糖胺聚糖的特征基团。动物实验表明毛蚶糖胺聚糖SSG对正常小鼠的生长无明显的不良作用,SSG低、中、高剂量组(50mg/kg、100mg/kg、200mg/kg)均可显著提高正常小鼠和免疫低下小鼠胸腺、脾指数。

外文摘要：Three main fractions of the glycosaminoglycan isolated from Area Suhcrenate Lisehke （SSG） was fractionalized and purified in these assay, and the physico-chemical property of SSG and its effects on immune organs of Mice were studied. Results showed that the main structure of SSG and its three fractions were aminohexose, and the hexuronic acid and sulfate group were also found. The infi-ared spectrum results showed that SSG and its three fractions contained the characteristic group of glycosaminoglycan. The animal experiments showed that SSG had no harmful side effects on the growth of normal mice. Low, middle and high doses of SSG （50 mg/kg, 100 mg/kg and 200 mg/kg） can promoted evidently the thymus index and spleen index of normal mice or immunosuppression mice induced by Cyclophosphamide.