文献类型：期刊文献

英文题名：The role of dietary flavonoids for modulation of ATP binding cassette transporter mediated multidrug resistance

作者：Teng, Hui[1];Deng, Hongting[1];He, Yuanju[1];Lv, Qiyan[1];Chen, Lei[1]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol,Key Lab Adv Proc Aquat Pr, Guangdong Prov Engn Technol Res Ctr Seafood,Guang, Guangdong Prov Key Lab Aquat Product Proc & Safet, Zhanjiang 524088, Peoples R China

年份：2021

卷号：2

期号：5

起止页码：234

外文期刊名：EFOOD

收录：EI(收录号：20232614303875)、ESCI(收录号：WOS:001186777500002)、Scopus(收录号：2-s2.0-85129709937)、WOS

基金：This work is supported by the National Natural Science Foundation of China (NSFC, Grant No. 32072209, Grant No. 31801459); China Postdoctoral Science Foundation Funded Project (2020M682073); Science and Technology General Projects of Fujian Province (2019J01393).

语种：英文

外文关键词：Bioavailability; Intestine; Flavonoids; ATP binding cassette (ABC); transporter

外文摘要：Flavonoids are widely existing compounds with enormous pharmacological effects from food and medicine. However, the low bioavailability in intestinal absorption and metabolism limits their clinical application. Intestinal efflux ABC (ATP binding cassette) transporters, including P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidrug resistance- associated proteins (MRPs), act as ''pumping doors" to regulate the efflux of flavonoids from intestinal epithelial cells into the intestinal cavity or the systemic circulation. The present review describes the critical effect of ABC transporters involved in the efflux of flavonoids which depend on its efflux direction. And the role of flavonoids for modulation of intestinal ABC transporters was emphasized and several examples were given. We summarized that the resistance effect of flavonoid-mediated multidrug on ABC transporters may influence the bioavailability of drugs, bioactive ingredients and/or toxic compounds upon dietary uptake. Meanwhile, flavonoids functionalized as reversing agents of the ABC transporter maybe an important mechanism for unexpected food-drug, food-toxin or food-food interactions. The overview also indicates that elucidation of the action and mechanism of the intestinal metabolic enzymes-efflux transporters coupling will lay a foundation for improving the bioavailability of flavonoids in vivo and increasing their clinical efficacy. (c) 2021 The Authors. Publishing services by Visagaa Publishing House This is an open access article distributed under the CC BY-NC 4.0 license (https://creativecommons.org/licenses/by/4.0/).