文献类型：期刊文献

英文题名：The effect mechanism of polysaccharides inhibit tumor immune escape: A review

作者：Yang, Kun[1];Chen, Jing[1];Chen, Jianping[1];Wang, Zhuo[1];Song, Bingbing[1];Li, Rui[1];Zhong, Saiyi[1,2,3];Cheong, Kit-Leong[1,2]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Prov Engn Technol Res Ctr Seafood, Guangdong Prov Sci & Technol Innovat Ctr Subtrop F, Zhanjiang 524088, Peoples R China;[2]Guangdong Ocean Univ, Shenzhen Res Inst, Shenzhen 518108, Peoples R China;[3]Dalian Polytech Univ, Collaborat Innovat Ctr Seafood Deep Proc, Dalian 116034, Peoples R China

年份：2023

卷号：107

外文期刊名：JOURNAL OF FUNCTIONAL FOODS

收录：SCI-EXPANDED(收录号：WOS:001038256800001)、、Scopus(收录号：2-s2.0-85163026261)、WOS

基金：This research project is supported by the Natural Science Foundation of Guangdong Province (2023A1515010005) and the Innovative Team Program of High Education of Guangdong Province (2021KCXTD021) .

语种：英文

外文关键词：Cancer; Polysaccharides; Immune escape; Immunomodulation

外文摘要：A disorder of the immune system is the fundamental cause of cancer. The body can defend against external threats only when the immune system is robust. Polysaccharides are natural immune regulators that can regulate the immune function of the body at multiple levels and targets. Recent studies have shown that polysaccharides can inhibit tumor growth by stimulating the immune system, thereby promoting immune cell proliferation, increasing cytokine secretion, and regulating the immune functions of the body as a whole. However, there are few reports on the potential mechanism by which polysaccharides inhibit tumor immune escape. Therefore, this article reviews the immune anti-tumor effect of polysaccharides, the mechanism by which they inhibit tumor immune escape, and their signaling pathways, in order to provide a theoretical basis for the development of anti-tumor drugs and malignant tumor treatment.