文献类型：期刊文献

英文题名：Epidemiological and Phylogenetic Analysis of Reassorted H10Nx Avian Influenza Viruses in Guangdong Province, China

作者：Liu, Jie[1];Zhang, Qiyue[1];Xiang, Haiyang[2];Li, Yuanguo[2];Liu, Jing[1];Yao, Qiucheng[1];Gao, Yuwei[2];Ge, Ye[1]

机构：[1]Guangdong Ocean Univ, Coll Coastal Agr Sci, Zhanjiang, Peoples R China;[2]Chinese Acad Agr Sci, Changchun Vet Res Inst, State Key Lab Pathogen & Biosecur, Key Lab Jilin Prov Zoonosis Prevent & Control, Changchun, Peoples R China

年份：2026

卷号：20

期号：9

外文期刊名：INFLUENZA AND OTHER RESPIRATORY VIRUSES

收录：SCI-EXPANDED(收录号：WOS:001884991400001)、、Scopus(收录号：2-s2.0-105051570377)、WOS

基金：The authors thank the authors and laboratories that submitted the AIV sequences to the GISAID and NCBI databases. This work was supported by the Guangdong Basic and Applied Basic Research Foundation (Grant Number 2024A1515010056) and the Natural Resource Affairs (Ecological Forestry Construction) Project of the Guangdong Forestry Department (Grant Numbers K25032 and K24181), and this work was also supported by the Science and Technology Development Fund of Macau SAR under Grant FDCT 0002/2024/RDP. We thank the Guangdong Zhanjiang Mangrove National Nature Reserve and Leizhou Forestry Administration for facilitating our fieldwork.

语种：英文

外文关键词：avian influenza virus; evolution; H10 subtype; reassortment; wild birds

外文摘要：Aims H10 subtype avian influenza viruses circulate widely among wild and domestic birds worldwide. These viruses have crossed species barriers to infect mammals, including humans, with cases of H10N3, H10N5 and H10N8 reported. During active surveillance in Guangdong Province, China, between 2023 and 2025, we isolated 10 H10Nx influenza A viruses from wild birds and domestic ducks. To characterise their epidemiology and evolutionary dynamics, we analysed public sequence and surveillance data and found H10 viruses across all inhabited continents, including more than 400 isolates from China.Methods Bayesian phylogeographic analysis revealed that China is an important transmission hub for Eurasian-lineage H10 viruses.Results Phylogenetic analysis of the 10 H10 genes placed them within the North American lineage. Reassortment analysis indicated that these 10 isolates underwent complex gene exchange with multiple influenza A subtypes, resulting in five distinct genotypes. Some gene segments were identical to those found in avian H10N5 viruses that infect humans, indicating genetic relatedness to human-infected strains, likely resulting from reassortment events. Notably, these isolates harboured several amino acid substitutions associated with mammalian adaptation. Frequent transmission at the wild bird-poultry interface highlights potential zoonotic risks.Conclusions Our findings highlight the importance of H10 viruses as a public health risk and the need for intensified active surveillance in wild birds and poultry.