文献类型：期刊文献

英文题名：Hepatoprotective Effect of Ultrafine Powder of Dendrobium officinale against Acetaminophen-Induced Liver Injury in Mice

作者：Kong, Song-Zhi[1];Lin, Guo-Sheng[2,3];Liu, Jing-Jing[2,3];Su, Ling-Ye[4,5];Zeng, Lei[4,5];Luo, Dan-Dan[2,5];Su, Zi-Ren[2,3];Wang, Hong-Feng[4,5]

机构：[1]Guangdong Ocean Univ, Fac Chem & Environm Sci, Zhanjiang 524088, Guangdong, Peoples R China;[2]Guangzhou Univ Chinese Med, Math Engn Acad Chinese Med, Guangzhou 510006, Guangdong, Peoples R China;[3]Guangzhou Univ Chinese Med, Guangdong Prov Key Lab New Drug Dev & Res Chinese, Guangzhou 510006, Guangdong, Peoples R China;[4]Guangdong Prov Key Lab Silviculture Protect & Uti, Guangzhou 510000, Guangdong, Peoples R China;[5]Guangdong Acad Forestry, Guangzhou 510520, Guangdong, Peoples R China

年份：2018

卷号：24

期号：2

起止页码：339

外文期刊名：FOOD SCIENCE AND TECHNOLOGY RESEARCH

收录：SCI-EXPANDED(收录号：WOS:000444362300019)、、WOS

基金：This work was supported by the special foundation for excellent young teachers of Guangdong Ocean University (No. 2014008), the natural science foundation of Guangdong Province (No. 2015A030310360), Forestry Science and Technology Innovational Specific Project of Guangdong Province (No. 2014KJCX019-02, 2016KJCX006 & 2017KJCX007).

语种：英文

外文关键词：Dendrobium officinale; ultrafine powder; acetaminophen; liver injury; antioxidant

外文摘要：The aim of this study was to investigate the hepatoprotective effect of ultrafine powder of Dendrobium officinale (UDO) against acetaminophen (APAP)-induced liver injury in mice. ICR mice were orally administered with UDO (100, 200, 400 mg/kg/day) for 14 days before intraperitoneal injection of APAP. The results showed that UDO exhibited a significant dose -dependently preventive effect on APAP-induced hepatotoxicity. Pretreatment with UDO significantly reduced the serum levels of alanine transaminase and aspartate aminotransferase. Histological examination indicated that administration with UDO alleviated inflammation and necrosis as well as ameliorated hepatocyte steatosis, especially at 200 and 400 mg/kg doses. Additionally, UDO markedly recovered the activities of glutathione, catalase and total antioxidant capacity, and decreased the content of malonaldehyde and reactive oxygen species. In summary, the results suggested that pretreatment with UDO exists potently hepatoprotective effects against APAP-induced liver damage, which may be related to the enhanced antioxidant capacity and inhibited lipid peroxidation.