文献类型：期刊文献

英文题名：Evaluation of the effects of three arsenolipids on liver damage based on element imbalance and oxidative damage

作者：Chen, Jiajia[1];Zhong, Yingxiong[1];Liu, Xiaofei[1];Wang, Zhuo[1];Chen, Jianping[1];Song, Bingbing[1];Li, Rui[1];Jia, Xuejing[1];Zhong, Saiyi[1,2,3];Kang, Xinhuang[4]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Prov Engn Technol Res Ctr Seafood, Guangdong Prov Key Lab Aquat Prod Proc & Safety,Gu, Zhanjiang 524088, Peoples R China;[2]Guangdong Ocean Univ, Shenzhen Res Inst, Shenzhen, Peoples R China;[3]Dalian Polytech Univ, Collaborat Innovat Ctr Seafood Deep Proc, Dalian, Peoples R China;[4]Guangdong Ocean Univ, Coll Chem & Environm, Zhanjiang, Peoples R China

年份：2023

卷号：4

期号：4

外文期刊名：EFOOD

收录：EI(收录号：20233014437884)、ESCI(收录号：WOS:001136682300009)、Scopus(收录号：2-s2.0-85165457342)、WOS

基金：This study was supported by the National Natural Science Foundation of China (Project No. 31972163), the National Key R&D Program of China (Project No. 2020YFD0901101), the Guangdong Province Key Field R&D Plan Project (Project No. 2020B1111030004), and the Guangdong Provincial University Science and Technology Innovation Team Project (Project No. 2021KCXTD021).

语种：英文

外文关键词：arsenolipids; element; liver damage; oxidative; qPCR

外文摘要：The International Agency for Research on Cancer has classified semimetal arsenic as a human carcinogen. Arsenic poisoning can severely impact human health. Arsenic can be classified into inorganic and organic arsenic, with arsenolipids (AsLs) belonging to the category of organic arsenic. The primary species of AsLs include arsenic-containing hydrocarbons (AsHCs), fatty acids, and phospholipids. AsLs are highly abundant in marine organisms and diet may be the primary source of exposure to AsLs. Although increasing evidence shows that AsLs are cytotoxic to humans, the specific toxicity and its mechanism remain unclear. This study aimed to evaluate the hepatotoxicity and possible mechanisms of the toxic effects of AsLs in mice. Three AsLs (AsHC 332, AsHC 346, and AsHC 374) were administered via gavage at a dose of 3 mg/kg for 4 weeks. The results showed that short-term exposure did not affect the normal growth and development of mice. However, it caused liver damage in mice, mainly by disrupting the metabolism of selenium, copper, zinc, and other elements related to the synthesis of antioxidant enzymes, thereby reducing the activity of antioxidant enzymes and the expression of related genes. The liver damage effect of AsHC 332 was the strongest among the three AsLs. Three arsenolipids exposure does cause liver damage in mice, mainly by reducing the activity of antioxidant enzymes and the expression of related genes. The liver damage effect of AsHC 332 was the strongest among the three arsenolipids.image