文献类型：期刊文献

英文题名：Chicken toll-like receptors and their significance in immune response and disease resistance

作者：Nawab, Aamir[1,2];An, Lilong[1];Wu, Jiang[1];Li, Guanghui[1];Liu, Wenchao[1];Zhao, Yi[1];Wu, Qimin[3];Xiao, Mei[1]

机构：[1]Guangdong Ocean Univ, Dept Anim Sci, Zhanjiang, Guangdong, Peoples R China;[2]PMAS Arid Agr Univ Rawalpindi, Fac Vet Med, Rawalpindi, Pakistan;[3]Guangdong Ocean Univ, Mech & Power Engn Coll, Zhanjiang, Guangdong, Peoples R China

年份：2019

卷号：38

期号：6

起止页码：284

外文期刊名：INTERNATIONAL REVIEWS OF IMMUNOLOGY

收录：SCI-EXPANDED(收录号：WOS:000493229100001)、、Scopus(收录号：2-s2.0-85074705577)、WOS

基金：This work was supported by the Science and Technology Planning Project of Guangdong Province, China (2010 B090400376).

语种：英文

外文关键词：Toll-like receptors; poultry health; infectious diseases; immune response; diseases resistance

外文摘要：Infectious diseases are a major challenge for the poultry industry that causes widespread production losses. Thus, management and control of poultry health and diseases are essential for the viability of the industry. Toll-like receptors are best characterized as membrane-bound receptors that perform a central role in immune homeostasis and disease resistance by recognition of pathogen-associated molecular patterns. In response to pathogen recognition, TLRs initiate both innate and adaptive immune responses which may help to develop immunomodulatory therapeutics for TLR associated diseases. Vaccination produces specific immunity in the animal's body towards pathogens. However, due to certain disadvantages of vaccines, (inactivation of attenuated pathogens into the virulent strains and weak immunogenicity of inactivated vaccines) there is a crucial need to develop the safe and effective therapeutic intervention. TLR ligands have been classified as a potential adjuvant against the infectious diseases in farm animals. TLR adjuvants induce both specific and nonspecific immune responses in chickens to combat several bacterial, viral and parasitic diseases. Therefore, the aim of this review was to explore the chicken TLR4 and their role in immune responses and disease resistance to develop disease resistance poultry breeds in future.