文献类型：期刊文献

英文题名：Fish gut-liver immunity during homeostasis or inflammation revealed by integrative transcriptome and proteome studies

作者：Wu, Nan[1];Song, Yu-Long[1,2];Wang, Bei[3];Zhang, Xiang-Yang[1,4];Zhang, Xu-Jie[1,5];Wang, Ya-Li[1];Cheng, Ying-Yin[1];Chen, Dan-Dan[1];Xia, Xiao-Qin[1];Lu, Yi-Shan[3];Zhang, Yong-An[1,6]

机构：[1]Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China;[2]Demorgen Bioinformat Technol Co Ltd, Wuhan 430072, Peoples R China;[3]Guangdong Ocean Univ, Fisheries Coll, Zhanjiang 524088, Peoples R China;[4]Univ Chinese Acad Sci, Beijing 100049, Peoples R China;[5]Shanghai Ocean Univ, Coll Fisheries & Life Sci, Shanghai 201306, Peoples R China;[6]State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China

年份：2016

卷号：6

外文期刊名：SCIENTIFIC REPORTS

收录：SCI-EXPANDED(收录号：WOS:000386846400001)、、Scopus(收录号：2-s2.0-84994247376)、WOS

基金：This work was funded by grants from the National Basic Research Program of China (2014CB138601), National Natural Science Foundation of China (31472307) and Knowledge Innovation Program of the Chinese Academy of Sciences (Y35E01-1-501). And we would like to give special thanks to Mr. Ming-Kun Yang (Institute of Hydrobiology, CAS) for helpful discussions and critical reviews.

语种：英文

外文摘要：The gut-associated lymphoid tissue, connected with liver via bile and blood, constructs a local immune environment of both defense and tolerance. The gut-liver immunity has been well-studied in mammals, yet in fish remains largely unknown, even though enteritis as well as liver and gallbladder syndrome emerged as a limitation in aquaculture. In this study, we performed integrative bioinformatic analysis for both transcriptomic (gut and liver) and proteomic (intestinal mucus and bile) data, in both healthy and infected tilapias. We found more categories of immune transcripts in gut than liver, as well as more adaptive immune in gut meanwhile more innate in liver. Interestingly reduced differential immune transcripts between gut and liver upon inflammation were also revealed. In addition, more immune proteins in bile than intestinal mucus were identified. And bile probably providing immune effectors to intestinal mucus upon inflammation was deduced. Specifically, many key immune transcripts in gut or liver as well as key immune proteins in mucus or bile were demonstrated. Accordingly, we proposed a hypothesized profile of fish gut-liver immunity, during either homeostasis or inflammation. Current data suggested that fish gut and liver may collaborate immunologically while keep homeostasis using own strategies, including potential unique mechanisms.