文献类型：期刊文献

英文题名：Toxic Effects of Bisphenol AF Exposure on the Reproduction and Liver of Female Marine Medaka (Oryzias melastigma)

作者：Li, Huichen[1];Gao, Jiahao[1];Liu, Yue[1];Ding, Yujia[1];Guo, Yusong[1];Wang, Zhongduo[1];Dong, Zhongdian[1,2];Zhang, Ning[1];Sinha, Amit Kumar

机构：[1]Guangdong Ocean Univ, Key Lab Aquaculture South China Sea Aquat Econ Ani, Coll Fishery, Zhanjiang 524088, Peoples R China;[2]Guangdong Ocean Univ, Coll Fishery, Guangdong Prov Key Lab Pathogen Biol & Epidemiol A, Zhanjiang 524088, Peoples R China

年份：2024

卷号：14

期号：2

外文期刊名：ANIMALS

收录：SCI-EXPANDED(收录号：WOS:001151761600001)、、Scopus(收录号：2-s2.0-85183114978)、WOS

基金：No Statement Available

语种：英文

外文关键词：aquatic ecosystem; bisphenols; endocrine disruptor; immune response; gene expression

外文摘要：In recent years, bisphenol AF (BPAF) in aquatic environments has drawn attention to its ecological risks. This study aims to investigate the toxic effects of BPAF (188.33 mu g/L) exposure for 30 days on female marine medaka (Oryzias melastigma). On the 10th and 30th day of exposure, the toxicity was evaluated using histological analysis of the liver and ovaries and the transcription levels of genes related to the antioxidant system, immune system, and hypothalamic-pituitary-gonadal (HPG) axis. Findings revealed that (1) BPAF exposure caused vacuolation, karyopyknosis and karyolysis in the liver of marine medaka, and the toxic impact augmented with duration; (2) exposure to BPAF for 10 days facilitated the growth and maturation of primary ova, and this exposure had a comparatively inhibitory effect after 30 days; (3) exposure to BPAF resulted in a biphasic regulation of the transcriptional abundance of genes involved in antioxidant and inflammatory response (e.g., il-8, cat), with an initial up-regulation followed by down-regulation. Additionally, it disrupted the transcriptional pattern of HPG axis-related genes (e.g., 3 beta hsd, ar alpha). In conclusion, 188.33 mu g/L BPAF can alter the expression levels of functionally related genes, impair the structural integrity of marine organisms, and pose a threat to their overall health.