文献类型：期刊文献

英文题名：Antioxidative and Protective Effect of Morchella esculenta against Dextran Sulfate Sodium-Induced Alterations in Liver

作者：Chen, Shutong[1,2];Wang, Min[3];Veeraperumal, Suresh[2];Teng, Bo[2];Li, Rui[1];Qian, Zhengming[4];Chen, Jianping[1];Zhong, Saiyi[1];Cheong, Kit-Leong[2]

机构：[1]Guangdong Ocean Univ, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Coll Food Sci Technol, Guangdong Prov Engn Lab Marine Biol Prod,Guangdong, Zhanjiang 524088, Peoples R China;[2]Shantou Univ, Coll Sci, Dept Biol, Shantou 515063, Peoples R China;[3]Guangdong Ocean Univ, Postgrad Coll, Zhanjiang 524088, Peoples R China;[4]Dongguan HEC Cordyceps R&D Co Ltd, Dongguan 523850, Peoples R China

年份：2023

卷号：12

期号：5

外文期刊名：FOODS

收录：SCI-EXPANDED(收录号：WOS:000948121200001)、、WOS

基金：This research was funded by the Key-Area Research and Development Program of Guangdong Province, grant number 2020B1111030004; The Innovative Team Program of High Education of Guangdong Province, grant number 2021KCXTD021; and The Program for Scientific Research Start-up Funds of Guangdong Ocean University.

语种：英文

外文关键词：Morchella esculenta; polysaccharide; antioxidant; ulcerative colitis; oxidative stress

外文摘要：Morchella esculenta is an edible mushroom with special flavor and high nutritional value for humans, primarily owing to its polysaccharide constituents. M. esculenta polysaccharides (MEPs) possess remarkable pharmaceutical properties, including antioxidant, anti-inflammatory, immunomodulatory, and anti-atherogenic activities. The aim of this study was to evaluate the in vitro and in vivo antioxidant potential of MEPs. In vitro activity was determined using free radical scavenging assays, whereas in vivo activity was evaluated through dextran sodium sulfate (DSS)-induced liver injury in mice with acute colitis. MEPs effectively scavenged 1,1-diphenyl-2-picrylhydrazyl and 2,2-azinobis-6-(3-ethylbenzothiazoline sulfonic acid) free radicals in a dose-dependent manner. Additionally, DSS-induced mice showed severe liver damage, cellular infiltration, tissue necrosis, and decreased antioxidant capacity. In contrast, intragastric administration of MEPs showed hepatoprotective effects against DSS-induced liver injury. MEPs remarkably elevated the expression levels of superoxide dismutase, glutathione peroxidase, and catalase. Additionally, it decreased malondialdehyde and myeloperoxidase levels in the liver. These results indicate that the protective effects of MEP against DSS-induced hepatic injury could rely on its ability to reduce oxidative stress, suppress inflammatory responses, and improve antioxidant enzyme activity in the liver. Therefore, MEPs could be explored as potential natural antioxidant agents in medicine or as functional foods to prevent liver injury.