文献类型：期刊文献

英文题名：Extraction and Characterization of Fucoidan Derived from Sargassum ilicifolium and Its Biomedical Potential with In Silico Molecular Docking

作者：Lakshmanan, Archana[1];Balasubramanian, Balamuralikrishnan[2];Maluventhen, Viji[3];Malaisamy, Arunkumar[4];Baskaran, Rathinasamy[5];Liu, Wen-Chao[6];Arumugam, Maruthupandian[1]

机构：[1]Periyar Univ, Dept Bot, Salem 636011, India;[2]Sejong Univ, Coll Life Sci, Dept Food Sci & Biotechnol, Seoul 05006, South Korea;[3]Thiagarajar Coll, Bot Dept, Madurai 625009, India;[4]Int Ctr Genet Engn & Biotechnol ICGEB, Transcript Regulat, New Delhi 110067, India;[5]Asia Univ, Dept Bioinformat & Med Engn, Taichung, Taiwan;[6]Guangdong Ocean Univ, Coll Coastal Agr Sci, Dept Anim Sci, Zhanjiang 524088, Peoples R China

年份：2022

卷号：12

期号：24

外文期刊名：APPLIED SCIENCES-BASEL

收录：SCI-EXPANDED(收录号：WOS:000902166800001)、、WOS

语种：英文

外文关键词：fucoidan; Sargassum ilicifolium; characterization; antioxidant anticoagulant; anticancer activities; in silico docking

外文摘要：Fucoidan, a polymer derived from seaweed, poses a broad range of biological applications, and its potential medicinal benefits have been widely studied over the past decade. In this study, fucoidan was extracted from marine macroalga Sargassum ilicifolium and its bioactive potential for in silico molecular docking was investigated. Additionally, the computational in silico docking studies were applied on the fucoidan against anticancer and antioxidant target proteins by using Glide ligand docking, Schrodinger software. The FT-IR analysis revealed that fucoidan mainly consisted of the fucose residues (59.1%) and a few monosaccharides, such as uronic acid (11.7%) and sulphate (18.3%). The in vitro tests revealed that fucoidan possessed various antioxidative properties and anticoagulant activities. Fucoidans played an inhibitory role in the colony formation of HepG2 cells. The NADPH oxidase (-7.169 Kcal/mol) and cellular tumor antigen p53 protein (-6.205 Kcal/mol) exhibited the highest antioxidant and anticancer proteins, respectively. Overall, the present study results provide a theoretical foundation for broadening the application of fucoidan from S. ilicifolium as a pharmaceutical ingredient.