文献类型：期刊文献

中文题名：珠母贝糖胺聚糖对鸡胚绒毛尿囊膜血管生成的影响

英文题名：Effect of glycosaminoglycan from Pinctada martensii on angiogenesis of chick chorioallantoic membrane

作者：吴红棉[1];蒋巧俊[1];范秀萍[1];胡雪琼[1];叶庆俊[1]

机构：[1]广东海洋大学食品科技学院,广东湛江524006

年份：2008

卷号：24

期号：3

起止页码：374

中文期刊名：中国药理学通报

外文期刊名：Chinese Pharmacological Bulletin

收录：CSTPCD、、北大核心2004、Scopus、CSCD2011_2012、北大核心、CSCD

基金：广东省教育厅自然研究资助项目(No04J006)

语种：中文

中文关键词：珠母贝糖胺聚糖;血管生成;鸡胚绒毛尿囊膜

外文关键词：glycosaminoglycan from Pinctada martensii; angiogenesis ; CAM

中文摘要：目的探讨珠母贝糖胺聚糖的抗肿瘤作用机制。方法采用鸡胚绒毛尿囊膜(CAM)模型观察珠母贝糖胺聚糖单用及与5-氟尿嘧啶(5-FU)合用对CAM血管生成的影响。结果珠母贝糖胺聚糖CPG、PGⅠ、PGⅡ在实验所选剂量(0·5、5、50、500mg·L-1)下,无明显的直接抑制CAM血管生成作用;但CPG、PGⅠ、PGⅡ在实验所选剂量(5、50mg·L-1)下与5-FU(2·5mg·L-1)合用时,均能增敏5-FU的抑制CAM血管生成作用(P<0·01),并呈一定的剂量效应关系,其中PGⅡ增敏效果较好。结论珠母贝糖胺聚糖通过抑制肿瘤血管生成而对5-FU的抗肿瘤作用起增敏效果。

外文摘要：Aim To study the antitumor mechanism of glycosaminoglycan from Pinctada martensii. Methods In vivo, the effects of glycosaminoglycan from Pinctada martensii on neovascularization was observed by chick chorioallantoic membrane （CAM） model. Re＇ suits CPG. PG Ⅰ . PG Ⅱ had no obvious anti-angiogenesis ability at the dosage of 0. 5 - 500 mg· L^-1, but they could enhance the anti-angiogenesis ability of 5-FU （2. 5 mg· L^-1 ） at the dosage of 5 - 50 mg · L^-1（ P 〈 0. 01 ） in a concentration-dependent manner. The anti-angiogenesis ability of PG 11 was better than that of CPG and PG I. Conclusions The glycosaminoglycan from Pinctada martensii has the effect of antiangiogenesis, which may be one mechanism of the synergistic effect of 5-FU on cancer cells.