文献类型：期刊文献

英文题名：Chitosan-modified Liposomes for Improved Oral Delivery of Dihydromyricetin: Synergistic Stabilization, pH-responsive Release and Markedly Enhanced Bioaccessibility

作者：Teng, Hui[1]; Yan, Minyi[1]; Chen, Chong[1]; Ai, Chao[1]; Huo, Huangjuan[1]; Chen, Lei[1]

机构：[1] College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Guangdong Provincial Engineering Technology Research Center of Prefabricated Seafood Processing and Quality Control, Zhanjiang, 524088, China

年份：2026

外文期刊名：SSRN

收录：EI(收录号：20260103866)

语种：英文

外文关键词：Biochemistry - Electrostatics - Encapsulation - Physicochemical properties - Stability

外文摘要：In this study, chitosan-modified dihydroberberine liposomes (CHI-DMY-Lips) were developed via electrostatic adsorption to overcome the low bioavailability of dihydroberberine (DMY). Employing conventional dihydroberberine liposomes (DMY-Lips) as controls, a comprehensive assessment was conducted on the physicochemical properties, activity preservation, in vitro release kinetics, along with the structural stability and bioaccsessbility during simulated gastrointestinal (GI) digestion of the delivery system. CHI-DMY-Lips exhibited a positive surface charge with larger size, more uniform distributions, and higher encapsulation efficiency (54.00% compared to 41.01% in DMY-Lips). The encapsulation by liposomes preserved the antioxidant activity of DMY, whereas, CHI further augmented its activity through synergistic effects. CHI-DMY-Lips presented enhanced structural and electrostatic stability during storage and superior in vitro sustained-release performance (especially at pH 7.4). Besides, CHI-DMY-Lips retained structural integrity throughout GI digestion and preserved its effective concentration and activity, resulting in a bioaccessibility approximately threefold that of free DMY (25.97% vs. 9.73%). ? 2026, The Authors. All rights reserved.