文献类型：期刊文献

英文题名：Ochratoxin A as an alarming health threat for livestock and human: A review on molecular interactions, mechanism of toxicity, detection, detoxification, and dietary prophylaxis

作者：Liu, Wen-Chao[1];Pushparaj, Karthika[2];Meyyazhagan, Arun[3];Arumugam, Vijaya Anand[4];Pappuswamy, Manikantan[3];Bhotla, Haripriya Kuchi[1];Baskaran, Rathinasamy[5];Issara, Utthapon[6];Balasubramanian, Balamuralikrishnan[7];Khaneghah, Amin Mousavi[8]

机构：[1]Guangdong Ocean Univ, Coll Coastal Agr Sci, Dept Anim Sci, Zhanjiang 524088, Peoples R China;[2]Avinashilingam Inst Home Sci & Higher Educ Women, Sch Biosci, Dept Zool, Coimbatore 641043, Tamil Nadu, India;[3]CHRIST Deemed Be Univ, Dept Life Sci, Bengaluru 560076, Karnataka, India;[4]Bharathiar Univ, Dept Human Genet & Mol Biol, Coimbatore 641046, Tamil Nadu, India;[5]Asia Univ, Dept Bioinformat & Med Engn, Taichung, Taiwan;[6]Rajamangala Univ Technol Thanyaburi, Fac Sci & Technol, Div Food Sci & Technol Management, Pathum Thani 12110, Thailand;[7]Sejong Univ, Coll Life Sci, Dept Food Sci & Biotechnol, Seoul 05006, South Korea;[8]Univ Campinas UNICAMP, Fac Food Engn, Dept Food Sci & Nutr, Monteim Lobato 80,Caixa Postal 6121, BR-13083862 Sao Paulo, SP, Brazil

年份：2022

卷号：213

起止页码：59

外文期刊名：TOXICON

收录：SCI-EXPANDED(收录号：WOS:000793768800008)、、Scopus(收录号：2-s2.0-85129290299)、WOS

基金：The authors were grateful to the authorities of their institutes for their support. The authors are grateful to the National Research Foundation of South Korea (2018R1C1B5086232) by the Korean Government (MEST).

语种：英文

外文关键词：Ochratoxin; Toxicokinetics; Biotransformation; Detoxification; Dietary prophylaxis

外文摘要：Ochratoxin A (OTA) is a toxic metabolite produced by Aspergillus and Penicillium fungi commonly found in raw plant sources and other feeds. This review comprises an extensive evaluation of the origin and proprieties of OTA, toxicokinetics, biotransformation, and toxicodynamics of ochratoxins. In in vitro and in vivo studies, the compatibility of OTA with oxidative stress is observed through the production of free radicals, resulting in genotoxicity and carcinogenicity. The OTA leads to nephrotoxicity as the chief target organ is the kidney. Other OTA excretion and absorption rates are observed, and the routes of elimination include faeces, urine, and breast milk. The alternations in the Phe moiety of OTA are the precursor for the amino acid alternation, bringing about Phe-hydroxylase and Phe-tRNA synthase, resulting in the complete dysfunction of cellular metabolism. Bio-detoxification using specific microorganisms decreased the DNA damage, lipid peroxidation, and cytotoxicity. This review addressed the ability of antioxidants and the dietary components as prophylactic measures to encounter toxicity and demonstrated their capability to counteract the chronic exposure through supplemen-tation as feed additives.