文献类型：期刊文献

中文题名：河蚬肉酶解产物解酒护肝功效

英文题名：Study on the anti-alcohol and liver-protection efficacy of hydrolysate from soft tissue of Corbicula fluminea

作者：张帅[1];章超桦[1,2,3,4];高加龙[1,2,3,4];秦小明[1,2,3,4];郑惠娜[1,2,3,4];郝记明[1,2,3,4];张静[1,2,3,4]

机构：[1]广东海洋大学食品科技学院,广东湛江524088;[2]广东省水产品加工与安全重点实验室,广东湛江524088;[3]广东普通高等学校水产品深加工重点实验室,广东湛江524088;[4]国家贝类加工技术研发分中心(湛江),广东湛江524088

年份：2019

卷号：35

期号：3

起止页码：166

中文期刊名：食品与机械

外文期刊名：Food and Machinery

收录：CSTPCD、、北大核心2017、北大核心

基金：广东省应用型科技研发专项资金项目(编号:2016B020235002);广东普通高等学校水产品高值化加工与利用创新团队项目(编号:GDOU2016030503);贝类产业技术体系(编号:CARS-49)

语种：中文

中文关键词：河蚬;酶解产物;解酒;护肝

外文关键词：Corbicula fluminea;hydrolysate;anti-alcohol;liver-protection

中文摘要：采用体外试验法测定河蚬肉酶解产物对乙醇脱氢酶(ADH)活性的影响,采用动物试验测定灌胃河蚬肉酶解产物后小鼠醉酒时间、醒酒时间、血液乙醇浓度的变化以及小鼠肝组织中丙二醛(MDA)、甘油三酯(TG)、谷胱甘肽(GSH)等相关生化指标评价其解酒护肝的功效。体外试验表明:河蚬肉酶解产物对ADH具有激活作用,激活率为52%。动物试验表明:河蚬肉酶解产物组与阴性组比较,可显著延长小鼠的醉酒时间和缩短醒酒时间,时间延长率为69.42%,缩短率为13.40%,且能显著降低小鼠血液乙醇浓度(P<0.05)。此外,河蚬肉酶解产物能显著降低小鼠肝组织中的MDA、TG的含量(P<0.05),减缓GSH的消耗(P<0.05)。综上可知河蚬肉酶解产物具有解酒护肝的功效。

外文摘要：The effect of hydrolysate fromCorbicula flumineasoft tissue on the activation of alcohol dehydrogenase(ADH)in vitro was determined,and its effects of anti-alcohol and liverprotection on mice were also observed by measuring the drunk time,sober-up time,concentration of ethanol in serum,and the contents of malondialdehyde(MDA),triglyceride(TG)and glutathione(GSH)in liver tissue of mice.The results showed that hydrolysate from soft tissue of Corbicula fluminea could activate ADH in vitro with activation rate of 52%.It could also prolong the drunk time and shorten the sober-up time of drunken mice significantly,by 69.42% and 13.40%,respectively,with the comparation of the negative group.It reduced the concentration of ethanol in mice serum significantly(P<0.05)and the contents of MDA and TG in liver tissue of mice significantly(P<0.05),and slowed down the consumption of GSH in mice significantly(P<0.05).Therefore,the hydrolysate from Corbicula fluminea soft tissue could activate ADH in vitro,with the function of anti-alcohol and protecting liver in drunk mice.