文献类型：期刊文献

英文题名：D-α-tocopherol polyethylene glycol 1000 succinate-based microemulsion delivery system: Stability enhancement of physicochemical properties of luteolin

作者：Zheng, Yimei[1,2];Zhao, Chengang[1];Chen, Boyu[1];Teng, Hui[1];Ai, Chao[1];Chen, Lei[1,2]

机构：[1]Guangdong Ocean Univ, Key Lab Adv Proc Aquat Prod Guangdong Higher Educ, Coll Food Sci & Technol, Guangdong Prov Engn Technol Res Ctr Seafood,Guangd, Zhanjiang 524088, Peoples R China;[2]Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Fujian, Peoples R China

年份：2023

卷号：426

外文期刊名：FOOD CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:001059706400001)、、EI(收录号：20232614323150)、Scopus(收录号：2-s2.0-85163354459)、WOS

基金：This work is supported by the National Natural Science Foundation of China (NSFC, Grant No. 32272315, 32072209); the Natural Science Foundation of Guangdong Province (2022A1515010694), the Innovative Team Program of High Education of Guangdong Province (2021KCXTD021).

语种：英文

外文关键词：Luteolin; SMEDDS; D-alpha-Tocopherol polyethylene glycol 1000; succinate; Stability

外文摘要：In the present study, D-alpha-Tocopherol polyethylene glycol 1000 succinate-based self-microemulsifying drug delivery systems (TPGS-SMEDDS) were introduced to enhance the solubility and stability of luteolin. The ternary phase diagrams were constructed to obtain the maximum area of microemulsion and suitable formulations of TPGS-SMEDDS. The particle size distribution and polydispersity index of selected TPGS-SMEDDS were analyzed to be less than 100 nm and 0.4, respectively. The thermodynamic stability results suggested that the TPGS-SMEDDS was stable during the heat-cool and freeze-thaw cycle. Moreover, the TPGS-SMEDDS exhibited excellent encapsulation capacity (51.21 +/- 4.39 to 85.71 +/- 2.40%) and loading efficiency (61.46 +/- 5.27 to 102.86 +/- 2.88 mg/g) to luteolin. In addition, the TPGS-SMEDDS showed an admirable vitro release ability with a ratio of more than 88.40 +/- 1.14% for luteolin in 24 h. Therefore, TPGS-based SMEDDS might provide an effective role for the oral administration of luteolin and holds promise as a potential delivery for poorly soluble bioactive compounds.