文献类型：期刊文献

英文题名：Boiled Abalone Byproduct Peptide Exhibits Anti-Tumor Activity in HT1080 Cells and HUVECs by Suppressing the Metastasis and Angiogenesis in Vitro

作者：Gong, Fang[1];Chen, Mei-Fang[1];Chen, Jiali[1];Li, ChengYong[2,3];Zhou, ChunXia[1];Hong, PengZhi[1];Sung, ShengLi[2];Qian, Zhong-Ji[2,3]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524088, Guangdong, Peoples R China;[2]Guangdong Ocean Univ, Sch Chem & Environm, Zhanjiang 524088, Guangdong, Peoples R China;[3]Guangdong Ocean Univ, Shenzhen Inst, Shenzhen 518114, Guangdong, Peoples R China

年份：2019

卷号：67

期号：32

起止页码：8855

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:000481563600015)、、WOS

基金：The research was funded by the Yangfan Scarce Top Talent Project of Guangdong Province (201433009) and the Program for Postgraduate Courses and Education Reform and Scientific Research Start-Up Funds of Guangdong Ocean University (to Z.-J.Q). Additional support was provided by Guangdong Tongde Pharmaceutical Co., Ltd. and the National Engineering Research Center for Modernization of Traditional Chinese Medicine (Lingnan Medicinal Plant Oil Branch) and by the Development Project about Marine Economy Demonstration of Zhanjiang City (2017C8B1).

语种：英文

外文关键词：Haliotis discus hannai; boiled abalone byproduct peptide; anti-metastasis; anti-angiogenesis; HT1080 cells; HUVECs

外文摘要：Abalone (Haliotis discus hannai) is a precious seafood in the market. It has been reported that biological active substances derived from abalone have anti-oxidative, anti-inflammatory, anti-bacterial, and anti-thrombosis potential. However, there were few studies to assess whether they have anti-cancer potential. In this study, we evaluated the anti-metastasis and antipro-angiogenic factors and mechanism of action of boiled abalone byproduct peptide (BABP, EMDEAQDPSEW) in human fibrosarcoma (HT1080) cells and human umbilical vein endothelial cells (HUVECs). The results demonstrated that BABP treatment significantly lowers migration and the invasion of HT1080 cells and HUVECs. BABP inhibits phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase (MMP) expression and activity by blocking mitogen-activated protein kinases (MAPKs) and NF-kappa B signaling and hypoxia-induced vascular endothelial growth factor (VEGF) secretion and hypoxia inducible factor (HIF)-1 alpha accumulation through suppressing the AKT/mTOR signal pathway. BABP treatment inhibits VEGF-induced VEGFR-2 expression and tube formation in HUVECs. The effect of BABP on anti-metastatic and anti-vascular activity in HT1080 cells and HUVECs revealed that BABP may be a potential pharmacophore for tumor therapy in the future.