文献类型：期刊文献

英文题名：Walnut protein hydrolysates ameliorate alcohol-induced cognitive impairment (AICI) by alleviating oxidative stress and inflammation in the brain and improving hippocampal synaptic plasticity in Sprague-Dawley rats

作者：Xu, Defeng[1,2];Zhao, Mouming[3]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524088, Guangdong, Peoples R China;[2]Guangdong Prov Engn Technol Res Ctr Marine Food, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang 524088, Guangdong, Peoples R China;[3]South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510640, Peoples R China

年份：2022

卷号：13

期号：22

起止页码：11615

外文期刊名：FOOD & FUNCTION

收录：SCI-EXPANDED(收录号：WOS:000870781000001)、、EI(收录号：20224613102677)、Scopus(收录号：2-s2.0-85141638834)、WOS

基金：The authors gratefully acknowledge the State Key Research and Development Plan (no. 2017YFD0400200) and the Fundamental Research Funds for the Central Universities (no. 20152M062) for the financial support.

语种：英文

外文关键词：Amino acids - Brain - Hydrolysis - Pathology - Proteins - Rats - Tissue

外文摘要：Alcohol-induced cognitive impairment (AICI) has become a public health concern and thus effective intervention is urgently needed. The present study aims to assess the amelioration effect of walnut protein hydrolysate (WPH) in AICI rats and elucidate the associated mechanism. The Morris water maze task verified the significant amelioration effect of WPH against learning and memory deficits. Moreover, a reduction of oxidative stress and inflammation in brain tissues was observed and the significant enhancement of brain-derived neurotrophic factor (BDNF), postsynaptic density protein (PSD95) and cAMP-response element binding protein (p-CREB) expression (P < 0.05) indicated the rescue of damaged hippocampal synaptic plasticity. In addition, after WPH administration, disorders of ERK and caspase-3 signal pathways, abnormality in the release of the neurotransmitters acetylcholine (ACh) and gamma-aminobutyric acid (GABA), and histopathological impairment in the hippocampus of AICI rats were ameliorated in a dose-dependent manner. Overall, the amelioration of AICI by WPH might result from the alleviation of oxidative stress and inflammation in brain tissue and the improvement of hippocampal synaptic plasticity.