文献类型：期刊文献

英文题名：Improvement of solubility, stability and antioxidant activity of carotenoids using deep eutectic solvent-based microemulsions

作者：Li, Yan[1,2];Hu, Kun[1];Huang, Chao[1];Hu, Yong[1];Ji, Hongwu[2];Liu, Shucheng[2];Gao, Jing[1,2]

机构：[1]Guangdong Pharmaceut Univ, Coll Food Sci, Zhongshan, Peoples R China;[2]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang, Peoples R China

年份：2022

卷号：217

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：SCI-EXPANDED(收录号：WOS:000818777500001)、、EI(收录号：20222412213561)、Scopus(收录号：2-s2.0-85131462240)、WOS

基金：Acknowledgements This work was supported by the National Natural Science Foundation of China (22078070) ; Natural Science Foundation of Guangdong Prov-ince (2019A1515010640) ; and Guangdong Innovation Team of Seafood Green Processing Technology (2019KCXTD011) .

语种：英文

外文关键词：Deep eutectic solvent; Microemulsion; Carotenoid; Solubility; Stability

外文摘要：Natural carotenoids have been widely used as colorants and antioxidants in process of food, medicine, and cosmetic. However, the carotenoids have low bioactivity in vivo due to poor water-solubility. To enhance the solubility, stability and antioxidant activity of carotenoids, novel microemulsions (MEs) composed with deep eutectic solvents (DESs), tween 80 and water were developed as alternatives to organic solvents. The phase diagrams and physicochemical properties (viscosity, pH, and diameter) of the DES-based MEs were investigated at different temperatures. Then the solubility distribution, storage stability and DPPH free radical-scavenging activity of three carotenoids (astaxanthin, astaxanthin ester and lutein) in the MEs were evaluated. Compared with ethanol, methanol, and acetone, all the DES-based MEs studied significantly enhanced the solubility of the carotenoids due to the stronger hydrogen bonding and Van der Waals interactions. The highest solubilities of 0.27, 473.63, and 12.50 mg/mL for astaxanthin, astaxanthin ester and lutein, respectively, were observed in the MEs containing DES (DL-menthol:acetic acid = 1:2) at 35 & DEG;C. Moreover, astaxanthin ester can be well preserved in the MEs containing DES (DL-menthol:octanoic acid = 1:2) with a half-life of more than 69 days. In addition, the DPPH scavenging capacities of the three carotenoids in all the MEs were higher than the organic solvents. The results revealed that the DES-based MEs with low viscosity (< 0.2 Pa & BULL;s) and mild acidic pH (4-5) are potential solvents for natural carotenoids in food processing and storage, medicine making, as well as biomaterials processing.