文献类型：期刊文献

英文题名：Progress and future prospect of in vitro spermatogenesis

作者：Ibtisham F.; Wu J.; Xiao M.; An L.; Banker Z.; Nawab A.; Zhao Y.; Li G.

机构：[1]Agricultural College, Guangdong Ocean University, Zhanjiang, Guangdong, China;[2]Foreign Language College, Guangdong Ocean University, Zhanjiang, Guangdong, China

年份：2017

卷号：8

期号：39

起止页码：66709

外文期刊名：Oncotarget

收录：Scopus(收录号：2-s2.0-85030095701)

语种：英文

外文关键词：Chemotherapy; In-vitro spermatogenesis; Infertility; Radiotherapy

外文摘要：Infertility has become a major health issue in the world. It affects the social life of couples and of all infertility cases; approximately 40-50% is due to "male factor" infertility. Male infertility could be due to genetic factors, environment or due to gonadotoxic treatment. Developments in reproductive biotechnology have made it possible to rescue fertility and uphold biological fatherhood. In vitro production of haploid male germ cell is a powerful tool, not only for the treatment of infertility including oligozoospermic or azoospermic patient, but also for the fertility preservation in pre-pubertal boys whose gonadal function is threatened by gonadotoxic therapies. Genomic editing of in-vitro cultured germ cells could also potentially cure flaws in spermatogenesis due to genomic mutation. Furthermore, this ex-vivo maturation technique with genomic editing may be used to prevent paternal transmission of genomic diseases. Here, we summarize the historical progress of in vitro spermatogenesis research by using organ and cell culture techniques and the future clinical application of in vitro spermatogenesis. ? Ibtisham et al.