文献类型：专著

英文题名：Zebrafish models of anxiety-like behaviors

作者：Collier A.D.[1,2];Kalueff A.V.[3,4,5,6];Echevarria D.J.[1,2]

机构：[1]Department of Psychology, University of Southern Mississippi, Hattiesburg, MS, United States;[2]The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, United States;[3]The International Zebrafish Neuroscience Research Consortium (ZNRC), ZENEREI Research Center, Slidell, LA, United States;[4]College of Food Science and Technology, Research Institute of Marine Drugs and Nutrition, Guangdong Ocean University, Zhanjiang, Guangdong, China;[5]Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russian Federation;[6]Institutes of Chemical Technology and Natural Sciences, Ural Federal University, Ekaterinburg, Russian Federation

出版社：Springer International Publishing

出版日期：0

纸书定价：0

isbn号：9783319337746; 9783319337739

语种：英文

外文关键词：Alarm pheromone; Anxiety; Behavioral phenotyping; Cortisol; Endocrine response; Light dark; Novel tank; Novelty; Open field; Predator stress; Strain differences; Stress; Zebrafish

外文摘要：Anxiety disorders are widespread psychiatric illnesses affecting approximately 7-10 % of the global population. Zebrafish are a particularly useful animal model for studying anxiety-related phenotypes. They are increasingly utilized for studying neurobiological, physiological and genetic mechanisms of anxiety, as well as for screening various anxiolytic drugs. Summarized here, accumulating evidence supports the utility of zebrafish neurobehavioral phenotyping in studying anxiety and stress neurobiology. For example, zebrafish are highly sensitive to various anxiety-evoking environmental stressors, including novelty, predator exposure, alarm pheromone, anxiogenic drugs, and drug withdrawal. Zebrafish also show high sensitivity to anxiolytic manipulations. Zebrafish anxiety-related neuroendocrine responses are also robust, sensitive, and correlate strongly (and bi-directionally) with behavioral endpoints. Finally, zebrafish are also amenable to genetic manipulations, and differences in baseline and experimentally-evoked anxiety levels can be observed in different strains of zebrafish. Collectively, this supports the validity and efficiency of both larval and adult zebrafish model for studying acute and chronic anxiety-like states. ? Springer International Publishing Switzerland 2017. All rights reserved.