文献类型：期刊文献

英文题名：Facile Synthesis of Anticancer Drug NCX 4040 in Mild Conditions

作者：Xiao, Mei[1,2,3];Yang, Hongsong[2];Klein, Suzane M.[1];Muenyi, Christian M.[2];Stone, William L.[2];Jiang, Yu L.[1]

机构：[1]E Tennessee State Univ, Dept Chem, Coll Arts & Sci, Johnson City, TN 37614 USA;[2]E Tennessee State Univ, Dept Pediat, Coll Med, Johnson City, TN 37614 USA;[3]Guang Dong Ocean Univ, Coll Agr, Dept Anim Med, Zhanjiang 524088, Guangdong, Peoples R China

年份：2008

卷号：5

期号：7

起止页码：510

外文期刊名：LETTERS IN ORGANIC CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:000260545700001)、、Scopus(收录号：2-s2.0-57349154368)、WOS

基金：This research is supported by the Office of Research and Sponsored Programs, Department of Chemistry and The McNair program at East Tennessee State University. We also thank the McNair program for providing a research internship to Mrs. Klein.

语种：英文

外文关键词：Anticancer drug; NCX 4040; design; synthesis; mild conditions; LNCaP cancer cell lines; prostate cancer

外文摘要：A simple method is reported to synthesize an anticancer drug, NCX 4040, conveniently in mild conditions using silicon chemistry. A starting material, 4-hydroxybenzyl alcohol, was silylated selectively first to give t-butyldimethylsilyl 4-hydroxybenzyl ether, which was then converted to NCX 4040 by esterification, desilylation, hydrochlorination and nitration.