文献类型：期刊文献

英文题名：Spirulina polysaccharide induces the metabolic shifts and gut microbiota change of lung cancer in mice

作者：Lu, Yingfang[1];Peng, Bo[2,3,4];Lin, Yuqi[1];Lin, Qianmin[1];Xia, Xuewei[1];Zhong, Saiyi[5];Luo, Lianxiang[6];Huang, Riming[1]

机构：[1]South China Agr Univ, Coll Food Sci, Guangdong Prov Key Lab Food Qual & Safety, Guangzhou 510642, Peoples R China;[2]Chinese Acad Sci, Guangzhou Inst Geochem, CAS Ctr Excellence Deep Earth Sci, State Key Lab Organ Geochem,Guangdong Prov Key Lab, Guangzhou 510640, Peoples R China;[3]CAS Ctr Excellence Deep Earth Sci, Guangzhou 510640, Peoples R China;[4]Univ Chinese Acad Sci, Beijing 100049, Peoples R China;[5]Guangdong Ocean Univ, Key Lab Adv Proc Aquat Prod,Guangdong Higher Educ, Coll Food Sci & Technol,Guangdong Prov Key Lab Aqu, Guangdong Prov Engn Technol Res Ctr Seafood,Guangd, Zhanjiang 524088, Peoples R China;[6]Guangdong Med Univ, Marine Biomed Res Inst, Marine Biomed Res Inst Guangdong Zhanjiang, Zhanjiang 524000, Peoples R China

年份：2022

卷号：5

起止页码：1313

外文期刊名：CURRENT RESEARCH IN FOOD SCIENCE

收录：SCI-EXPANDED(收录号：WOS:000917689100003)、、Scopus(收录号：2-s2.0-85136538456)、WOS

基金：Acknowledgments This work was financially supported by the Program of Department of Natural Resources of Guangdong Province (No. GDNRC [2021] 53) , the National Natural Science Foundation of China (No. 32161160304) , Key-Area Research and Development Program of Guangdong Province (No.2020B1111030004) , Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety (No. GDPKLAPPS2102) , and the Innovative Team Program of High Education of Guangdong Province (No. 2021KCXTD021) .

语种：英文

外文关键词：Spirulina; Polysaccharide; Lung cancer; Metabolomics; Gut microbiota

外文摘要：A polysaccharide obtained from Spirulina (PSP) and its effect on lung cancer in mice was investigated. Our results indicate that the tumor volume and weight of the lung cancer-bearing mice treated with PSP decreased signif-icantly. Metabolite analysis showed that 27 differential accumulated metabolites (DAMs) changed significantly, in which 24 DAMs increased while 3 DAMs decreased. KEGG enrichment results showed that these differential metabolites were enriched significantly in the high-affinity IgE receptor (Fc epsilon RI) signaling pathway and arach-idonic acid metabolism. In addition, PSP modulated gut microbiota of the lung cancer-bearing mice. PSP increased the abundance of Lactobacillus, Allobaculum, Alloprevotella, and Olsenella, decreasing Bacteroides and Acinetobacter. The results might be related to suppressing lung cancer. Based on our study, we hypothesized that PSP inhibited lung cancer through Fc epsilon RI signaling pathway and arachidonic acid metabolism and regulated the balance of gut microbiota. Nevertheless, the relationship between these two pathways and gut microbiota needs further study.