文献类型：期刊文献

中文题名：基于分子对接技术的牡蛎酶解产物中免疫调节肽筛选及其抗氧化作用

英文题名：Screening of immunomodulatory peptides from oyster enzymatic hydrolysates via molecular docking technology and evaluation of antioxidant properties

作者：Hongying, Wu[1]; Qianqian, Huang[1]; Xiaoming, Qin[1]; Wenhong, Cao[1]; Haisheng, Lin[1]

机构：[1] College of Food Science and Technology, Guangdong Ocean University, National Research and Development Branch Center for Shellfish Processing [Zhanjiang], Guangdong Provincial Key Laboratory of Aquatic Products Processing and Safety, Guangdong Provincial Engineering Technology Research Center of Seafood, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Prefabricated Seafood Processing and Quality Control, Zhanjiang, 524088, China

年份：2025

卷号：51

期号：15

起止页码：185

外文期刊名：Food and Fermentation Industries

收录：EI(收录号：20260519987008)

语种：中文

外文关键词：Antigen-antibody reactions - Antioxidants - Binding energy - Cell proliferation - Free radicals - Functional food - Molecular docking - Peptides - Plants (botany) - Scavenging - Shellfish

外文摘要：Screening of immunoactive peptides from oyster extracts was conducted using molecular docking technology, followed by in vitro experiments to assess their immunomodulatory and antioxidant properties. The results of molecular docking indicated that peptides LLQLGSGR (OP1) and DNSIAMESMK (OP2) exhibited strong binding affinities to Toll-like receptor 2 and Toll-like receptor 4, with binding energies of - 7. 7, - 6. 1 kcal/mol, and - 6. 3, - 4. 1 kcal/mol, respectively. The experiments in vitro with RAW264. 7 cells showed that OP1, at a concentration of 200 μg/mL, significantly increased NO production (P ? (2025), (China National Research Institute of Food and Fermentation Industries Co. Ltd). All rights reserved.