文献类型：期刊文献

英文题名：A Marine ACE Inhibitory Peptide SLPWPMKPMNLIE Exerts Neuroprotective Effects via RAS Modulation in SHSY-5Y Cells

作者：Zhu, Xiaoying[1]; Zhang, Yue[1]; Chen, Yanzhu[1]; Lai, Junlong[1]; Zheng, Zhiwei[1]; Wang, Yunpeng[1]; Zheng, Zhihong[1,2]; Lin, Haisheng[1,2]; Gao, Jialong[1,2]; Cao, Wenhong[1,2]; Xia, Xiaoyu[1,2]

机构：[1] College of Food Science and Technology, Guangdong Ocean University, National Research and Development Branch Center for Shellfish Processing [Zhanjiang], Guangdong Provincial Key Laboratory of Aquatic Products Processing and Safety, Shenzhen Institute of Guangdong Ocean University, Guangdong Provincial Engineering Technology Research Center of Seafood, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Prefabricated Seafood Processing and Quality Control, Zhanjiang, 524088, China; [2] Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian, 116034, China

年份：2026

外文期刊名：SSRN

收录：EI(收录号：20260254835)

语种：英文

外文关键词：Cytology - Functional food

外文摘要：With growing demand for functional foods, the multi-dimensional regulatory effects and mechanisms of food-derived bioactive molecules have drawn increasing attention. Here, we demonstrate that SLPWPMKPMNLIE, a potential hypotensive peptide from Pinctada martensii with ACE inhibitory capacity, protects SH-SY5Y cells against MPP+/Ang II-induced neurotoxicity. The peptide attenuates oxidative stress damage in SH-SY5Y cells, restores mitochondrial membrane potential and mitigates iron deposition via modulating the renin-angiotensin system. Specifically, the ACE/Ang II/AGTR1 axis was downregulated and the protective MAS1L was promoted, as a result, the expressions of neurotrophic factors was restored in SH-SY5Y cells. These findings reveal a RAS-modulating neuroprotective mechanism of the shellfish-derived ACE inhibitory peptide, providing novel insights into alleviating hypertension-related cognitive impairment. ? 2026, The Authors. All rights reserved.