文献类型：期刊文献

英文题名：Ribavirin inhibits peste des petits ruminants virus proliferation in vitro

作者：Zhang, Weifeng[1];Deng, Hualong[1];Liu, Yanfen[1];Chen, Shaohong[2];Liu, You[2];Zhao, Yuntao[2]

机构：[1]Guangdong Ocean Univ, Coll Coastal Agr Sci, Dept Anim Sci, Zhanjiang, Peoples R China;[2]Guangdong Ocean Univ, Coll Food Sci & Technol, Dept Bioengn, Zhanjiang, Peoples R China

年份：2023

卷号：68

期号：12

起止页码：464

外文期刊名：VETERINARNI MEDICINA

收录：SCI-EXPANDED(收录号：WOS:001136367700003)、、Scopus(收录号：2-s2.0-85186118341)、WOS

基金：Supported by a grant from the Guangdong Modern Agricultural Industrial System (2019K127) .

语种：英文

外文关键词：antiviral activity; antiviral drugs; mechanism; peste des petits ruminants; signal pathway

外文摘要：Peste des petits ruminants virus (PPRV), a member of the family Paramyxoviridae, belongs to the genus Morbillivirus. It causes devastating viral diseases in small ruminants and has been rapidly spreading over vari -ou s regions in Africa, the Middle East, and Asia. Although vaccination is thought to be an effective management strategy against PPR infections, the heat sensitivity of PPRV vaccines severely restricts their use in regions with hot climates. In this research, we studied the antiviral activities of ribavirin and aimed to understand the potential mechanisms of action of ribavirin in the African green monkey kidney cells (Vero cells). In brief, the adsorption, intrusion, replication, and release of PPRV, as well as the mRNA expression level of RNA-dependent RNA poly-merase (RdRp), were significantly inhibited in the ribavirin-treated Vero cells compared to those in the PPRV-infected cells that were not treated with ribavirin. Additionally, ribavirin has potential as an antiviral drug against PPRV, and its antiviral activity is mediated by the Janus kinase signal transducer and activator of transcription (JAK/STAT) and PI3K/AKT pathways.