文献类型：期刊文献

英文题名：Mechanism Analysis of Antiangiogenic D-Isofloridoside from Marine Edible Red algae Laurencia undulata in HUVEC and HT1080 cell

作者：Yang, Shengtao[1,2];Xiao, Zhenbang[1];Lin, Liyuan[1];Tang, Yanfei[1];Hong, Pengzhi[1,3];Sun, Shengli[1];Zhou, Chunxia[1,3];Qian, Zhong-Ji[1,3]

机构：[1]Guangdong Ocean Univ, Shenzhen Inst, Coll Food Sci & Technol, Sch Chem & Environm, Zhanjiang 524088, Guangdong, Peoples R China;[2]Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Key Lab Trop Crop Prod Proc, Minist Agr & Rural Affairs, Zhanjiang 524001, Peoples R China;[3]Southern Marine Sci & Engn Guangdong Lab, Zhanjiang 524025, Peoples R China

年份：2021

卷号：69

期号：46

起止页码：13787

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:000750860300014)、、WOS

基金：The research was funded by the 2020 Shenzhen International Scientific and Technological Cooperation R&D Project (GJHZ20190823111601682) and Guangdong Basic and Applied Basic Research Foundation (2020A1515011075). The supported by the Development Project about Marine Economy Demonstration of Zhanjiang City (XM-202008-01B1) and Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang, ZJW-2019-07).

语种：英文

外文关键词：Laurencia undulata; D-Isofloridoside; metastasis; angiogenesis; signal pathway

外文摘要：Laurencia undulata, as one of the most biologically active species in the genus Laurencia, is an edible folk herb red algae. Among them, D-isofloridoside (DIF, 940.68 Da) is isolated from Laurencia undulata, which has antioxidant and matrix metalloproteinases (MMP) inhibitory activities. However, its mechanism of action on tumor angiogenesis has not yet been reported. In this study, we have studied the mechanism of DIF on tumor metastasis and angiogenesis in HT1080 cell and human vascular endothelial cell (HUVEC). The results show that DIF can reduce the activity of MMP-2/9, and can inhibit the expression of hypoxia-inducible factor-1 alpha (HIF-1 alpha) by regulating the downstream PI3K/AKT and mitogen-activated protein kinases (MAPK) pathways, thereby down-regulating the production of vascular endothelial growth factor (VEGF) in CoCl2-induced HT1080 cell. In addition, DIF can inhibit the activation of VEGF receptor (VEGFR-2), regulate downstream PI3K/AKT, MAPK, nuclear factor-kappa B (NF-kappa B) signal pathways, activate apoptosis, and thus down-regulate the production of platelet-derived growth factor (PDGF) in VEGF-induced HUVEC. In conclusion, our research shows that DIF has the potential to develop into a tumor-preventing functional food and tumor angiogenesis inhibitor, and it can provide theoretical guidance for the high-value comprehensive utilization of edible red algae Laurencia undulata.