文献类型：期刊文献

英文题名：Advances in molecular identification, taxonomy, genetic variation and diagnosis of Toxocara spp.

作者：Chen, Jia[1,2];Zhou, Dong-Hui[1];Nisbet, Alasdair J.[3];Xu, Min-Jun[1];Huang, Si-Yang[1];Li, Ming-Wei[1,4];Wang, Chun-Ren[5];Zhu, Xing-Quan[1,5,6]

机构：[1]Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Key Lab Vet Parasitol Gansu Prov, State Key Lab Vet Etiol Biol, Lanzhou 730046, Gansu, Peoples R China;[2]S China Agr Univ, Coll Vet Med, Guangzhou 510642, Guangdong, Peoples R China;[3]Moredun Res Inst, Div Parasitol, Moredun EH26 0PZ, Midlothian, Scotland;[4]Guangdong Ocean Univ, Dept Vet Med, Coll Agr, Zhanjiang 524088, Guangdong, Peoples R China;[5]Heilongjiang Bayi Agr Univ, Coll Anim Sci & Vet Med, Daqing 163319, Heilongjiang Pr, Peoples R China;[6]Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Yunnan Province, Peoples R China

年份：2012

卷号：12

期号：7

起止页码：1344

外文期刊名：INFECTION GENETICS AND EVOLUTION

收录：SCI-EXPANDED(收录号：WOS:000310114600002)、、Scopus(收录号：2-s2.0-84865352456)、WOS

基金：Research in the authors' laboratories is supported, in part, by the Program for Outstanding Scientists in Agricultural Research, the Open Funds of the State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences (Grant Nos. SKLVEB2011KFKT004, SKLVEB2011KFKT011, SKLVEB2010KFKT009, SKLVEB2009KFKT008, and SKLVEB2011KFKT010) and the Yunnan Provincial Program for Introducing High-level Scientists (Grant No. 20090125).

语种：英文

外文关键词：Toxocara; Toxocariasis; Molecular identification; Molecular taxonomy; Genetic variation; Molecular diagnosis

外文摘要：The genus Toxocara contains parasitic nematodes of human and animal health significance, such as Toxocara canis, Toxocara cati and Toxocara vitulorum. T. canis and T. cad are among the most prevalent parasites of dogs and cats with a worldwide distribution. Human infection with T. canis and T. cati, which can cause a number of clinical manifestations such as visceral larva migrans (VLMs), ocular larva migrans (OLMs), eosinophilic meningoencephalitis (EME), covert toxocariasis (CT) and neurotoxocariasis, is considered the most prevalent neglected helminthiasis in industrialized countries. The accurate identification Toxocara spp. and their unequivocal differentiation from each other and from other ascaridoid nematodes causing VLMs and OLMs has important implications for studying their taxonomy, epidemiology, population genetics, diagnosis and control. Due to the limitations of traditional (morphological) approaches for identification and diagnosis of Toxocara spp., PCR-based techniques utilizing a range of genetic markers in the nuclear and mitochondria, genomes have been developed as useful alternative approaches because of their high sensitivity, specificity, rapidity and utility. In this article, we summarize the current state of knowledge and advances in molecular identification, taxonomy, genetic variation and diagnosis of Toxocara spp. with prospects for further studies. 2012 Elsevier B.V. All rights reserved.