文献类型：期刊文献

英文题名：Azaphilones isolated from an alga-derived fungus Penicillium sp ZJ-27

作者：Zhang, Liu-hong[1];Long, Yi[2];Lei, Xiao-ling[3];Xu, Jia-yi[1];Huang, Zhi-jian[1];She, Zhi-gang[2];Lin, Yong-cheng[2];Li, Jing[1,4];Liu, Lan[1,4]

机构：[1]Sun Yat Sen Univ, Sch Marine Sci, Guangzhou 510006, Guangdong, Peoples R China;[2]Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China;[3]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524025, Peoples R China;[4]Sun Yat Sen Univ, South China Sea Bioresource Exploitat & Utilizat, Guangzhou 510275, Guangdong, Peoples R China

年份：2016

卷号：18

起止页码：180

外文期刊名：PHYTOCHEMISTRY LETTERS

收录：SCI-EXPANDED(收录号：WOS:000389521800035)、、WOS

基金：The work was financially supported by National Natural Science Foundation of China [grant number 21272286] and China's Marine Commonweal Research Project [grant number 201305017]. We thank the High-Performance Grid Computing Platform of Sun Yat-Sen University for supporting the ECD calculations, and Jie Yuan from Zhongshan School of Medicine of Sun Yat-Sen University for the cytotoxicity assay.

语种：英文

外文关键词：Marine fungi; Alga; Secondary metabolites; Azaphilone; Penicillium sp

外文摘要：Four new azaphilones, peniazaphilones A-D (1-4), together with four analogues (5-8), were isolated from the alga-derived fungus Penicillium sp. ZJ-27. The structures of 1-8 were elucidated by 1D and 2D NMR analysis. The absolute configurations of 1-4 were determined by electronic circular dichroism (ECD). The isolated compounds were evaluated for cytotoxic activity against two tumor cell lines and antibacterial activities against twelve aquatic pathogenic bacteria. (C) 2016 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.