文献类型：期刊文献

英文题名：Self-assembled amphiphilic chitosan nanomicelles to enhance the solubility of quercetin for efficient delivery

作者：Wang, Hui[1,2];Yang, Ziming[1];He, Zuyu[1];Zhou, Chuang[1];Wang, Chao[1];Chen, Yu[4];Liu, Xianwu[2];Li, Sidong[3];Li, Puwang[1]

机构：[1]Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Key Lab Trop Crop Prod Proc, Minist Agr & Rural Affairs, Zhanjiang 524001, Guangdong, Peoples R China;[2]Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Hubei, Peoples R China;[3]Guangdong Ocean Univ, Coll Chem & Environm, Zhanjiang 524088, Peoples R China;[4]Beijing Inst Technol, Sch Mat Sci & Engn, 9 Beijing 100081, Peoples R China

年份：2019

卷号：179

起止页码：519

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：SCI-EXPANDED(收录号：WOS:000471736600059)、、EI(收录号：20191906883247)、Scopus(收录号：2-s2.0-85065062083)、WOS

基金：This work was supported by the Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences (No. 1630122017011, No. 1630122018009, No. 1630122019013), Science and technology projects of Zhanjiang (No. 2018A02015) and the Natural Science Foundation of Guangdong Province (No. 2018A030307015, No. 2018A030313109).

语种：英文

外文关键词：Self-assembled; Amphiphilic chitosan; Quercetin; Nanomicelles; Efficient delivery

外文摘要：Quercetin (QCT) has important functions such as antioxidant, anti-inflammatory and anticancer. However, its applications in food and in drug are restricted owing to its poor water solubility. In this work, a novel amphiphilic wall-material chitosan was synthesized via grafting of chitosan with deoxycholic acid (DA) as hydrophobic group and modified N-acetyl-L-cysteine (NAC) as hydrophilic group. Amphiphilic chitosan was self-assembled to load QCT as nanomicelles by a low-cost and inorganic solvent procedure. Both the encapsulation efficiencies (EE) and drug-loading rates (DL) increased when increasing the grafting rate of DA. There was a bursting release of QCT for the QCT-loaded nanomicelles (CS-DA-NAC-QNMs) from 0 to 8 h, and then the release rate decreased gradually. After releasing for 72 h, the final cumulative release percentages were more than 40%. All the QCT-loaded nanomicelles samples showed good hemocompatibility, and their water solubility and biocompatibility increased evidently. What's more, they exhibited an obvious inhibition rate of A549 cells.