文献类型：期刊文献

中文题名：围氏马尾藻岩藻聚糖硫酸酯对高脂血症小鼠脂质代谢的调节作用

英文题名：Regulatory Effects of Sargassum wightii Fucoidan on Lipid Metabolism of Hyperlipidemic Mice

作者：谌素华[1];王维民[1];蔡璐[1];钟思燕[1];钟赛意[1];谢恩义[2]

机构：[1]广东省水产品加工与安全重点实验室,广东普通高等学校水产品深加工重点实验室,广东海洋大学食品科技学院,广东湛江524088;[2]广东海洋大学水产学院,广东湛江524088

年份：2015

卷号：36

期号：19

起止页码：244

中文期刊名：食品科学

外文期刊名：Food Science

收录：CSTPCD、、北大核心2014、Scopus、北大核心、CSCD_E2015_2016、CSCD

基金：广东省自然科学基金项目(2015A030313618);广东省创新强校工程项目(GDOU2013041103);湛江市科技计划项目(2014A03017)

语种：中文

中文关键词：围氏马尾藻;岩藻聚糖硫酸酯;高脂血症;脂质代谢

外文关键词：Sargassum wightii; fucoidan; hyperlipidemia; lipid metabolism

中文摘要：目的:研究不同分子质量围氏马尾藻(Sargassum wigtii)岩藻聚糖硫酸酯对高脂血症小鼠脂质代谢的影响。方法:建立高脂血症小鼠模型,给小鼠灌胃中、低分子质量岩藻聚糖硫酸酯(MMWF1、MMWF2和LMWF1、LMWF2),测定小鼠体质量和肝脏指数以及血清脂质指标总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(high density lipoprotein cholesterol,LDL-C)含量,测定肝脏脂质指标TC、TG含量,探索岩藻聚糖硫酸酯的降脂效果。结果:灌胃4种不同分子质量的岩藻聚糖硫酸酯对高脂血症小鼠的体质量增长无显著影响,高剂量的4种岩藻聚糖硫酸酯可明显降低高脂血症小鼠的肝脏指数(P<0.05)。4种岩藻聚糖硫酸酯具有显著降低高脂血症小鼠血清和肝脏TG、TC、LDL-C含量(P<0.05),提高HDL-C含量(P<0.05)的作用,对动脉粥样硬化指数(atherosclerosis index,AI)也有明显降低效果(P<0.05),具有预防动脉粥样硬化生成的作用。结论:4种岩藻聚糖硫酸酯能够有效降低高脂血症小鼠血清和肝脏TC、TG含量,调节脂质代谢,有效缓解高脂血症,高剂量组作用最显著,剂量依赖性较明显。

外文摘要：The objective of this study was to examine the effects of Sargassum wightii fucoidans with different molecular weights on lipid metabolism of hyperlipidemic mice.Hyperlipidemic mouse models were established by gavaging medium molecular weight fractions（MMWFl and MMWF2） and low molecular weight fractions（LMWFl and LMWF2） of Sargassum wightii fucoidan.The body weights and liver indices of mice were measured.Serum indices such as total cholesterol（TC）,triglyceride（TG）,high-density lipoprotein cholesterol（HDL-C） and low-density lipoprotein cholesterol（LDL-C） and liver TC and TG levels were determined.The efficacy of Sargassum wightii fucoidan for reducing blood lipids was examined.Sargassum wightii fucoidan with four different molecular weights did not result in an obvious increase in body weights of experimental mice but at the high dosage significantly reduced liver indices of the mice（P〈0.05）.All four fucoidan fractions from Sargassum wightii significantly reduced serum TG,TC and LDL-C levels and liver TC and TG levels（P〈 0.05） and increased serum HDL-C level（P〈 0.05） of hyperlipidemic mice.They also significantly reduced atherosclerosis index（AI） and prevented the occurrence of atherosclerosis（P〈 0.05）,effectively reduced TC and TG levels,regulated lipid metabolism and effectively alleviated hyperlipidemia.Sargassum wightii fucoidan at the high dose revealed the most significant blood lipid-reducmg effect in a dose-dependent manner.