文献类型：期刊文献

英文题名：Molecular psychiatry of zebrafish

作者：Stewart, A. M.[1,2];Ullmann, J. F. P.[2,3];Norton, W. H. J.[2,4];Parker, M. O.[5];Brennan, C. H.[5];Gerlai, R.[6];Kalueff, A. V.[1,2,7]

机构：[1]ZENEREI Inst, Slidell, LA 70458 USA;[2]Int Zebrafish Neurosci Res Consortium, Slidell, LA USA;[3]Univ Queensland, Ctr Adv Imaging, Brisbane, Qld, Australia;[4]Univ Leicester, Coll Med Biol Sci & Psychiat, Dept Biol, Leicester, Leics, England;[5]Queen Mary Univ London, Sch Biol & Chem Sci, London, England;[6]Univ Toronto, Dept Psychiat, Mississauga, ON L5L 1C6, Canada;[7]Guangdong Ocean Univ, Coll Food Sci & Technol, Res Inst Marine Drugs & Nutr, Zhanjiang, Guangdong, Peoples R China

年份：2015

卷号：20

期号：1

起止页码：2

外文期刊名：MOLECULAR PSYCHIATRY

收录：SCI-EXPANDED(收录号：WOS:000349403400001)、、Scopus(收录号：2-s2.0-84908351502)、WOS

基金：The authors' research has been supported by grants from the National Institutes of Health (NIAAA AA015325-01A2 to RG, NIDA DA030900-02 to AVK and NINDS NS077295-01 to JFPU), the EU FP7 Framework Program (Grant 602805 to WHJN), as well as the National Center for the Replacement, Reduction and Refinement of Animals in Research (NC3Rs, UK, G1000053 to CHB) and the Medical Research Council (MRC, UK to CHB). CHB is a Royal Society (UK) Industrial Research Fellow. The study was coordinated and facilitated by the International Zebrafish Neuroscience Research Consortium (ZNRC). AVK is the Director of ZENEREI Institute and Chair of ZNRC.

语种：英文

外文摘要：Due to their well-characterized neural development and high genetic homology to mammals, zebrafish (Danio rerio) have emerged as a powerful model organism in the field of biological psychiatry. Here, we discuss the molecular psychiatry of zebrafish, and its implications for translational neuroscience research and modeling central nervous system (CNS) disorders. In particular, we outline recent genetic and technological developments allowing for in vivo examinations, high-throughput screening and whole-brain analyses in larval and adult zebrafish. We also summarize the application of these molecular techniques to the understanding of neuropsychiatric disease, outlining the potential of zebrafish for modeling complex brain disorders, including attention-deficit/hyperactivity disorder (ADHD), aggression, post-traumatic stress and substance abuse. Critically evaluating the advantages and limitations of larval and adult fish tests, we suggest that zebrafish models become a rapidly emerging new field in modern molecular psychiatry research.