文献类型：期刊文献

英文题名：Selenium nanoparticles stabilized by Sargassum fusiforme polysaccharides: Synthesis, characterization and bioactivity

作者：Chen, Yanzhe;Zhu, Feifei;Chen, Jianping[1];Liu, Xiaofei;Li, Rui;Wang, Zhuo;Cheong, Kit -Leong;Zhong, Saiyi

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang, Peoples R China; Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang, Peoples R China; Guangdong Prov Engn Technol Res Ctr Seafood, Zhanjiang, Peoples R China; Guangdong Prov Engn Lab Marine Biol Prod, Zhanjiang, Peoples R China; Guangdong Prov Modern Agr Sci & Technol Innovat Ct, Zhanjiang, Peoples R China

年份：2024

卷号：269

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：SCI-EXPANDED(收录号：WOS:001240990300004)、、EI(收录号：20241916058276)、Scopus(收录号：2-s2.0-85192324682)、WOS

基金：This research was funded by the Project of Science and Technology of Zhanjiang City (grant number: 2022A01045) , the Nanhai Youth Scholar Project of Guangdong Ocean University (grant number: 002029002009) , Scientific research start-up funds of Guangdong Ocean University (grant number: R19017) , Guangdong Basic and Applied Basic Research Foundation (grant number: 2021A1515012455) , the Guangdong Province Ordinary Universities Characteristic Innovation Project (grant number: 2020KTSCX051) , and the Guangdong Provincial Department of Education and the Innovative Team Program of High Education of the Guangdong Province (grant number: 2021KCXTD021) .

语种：英文

外文摘要：Selenium nanoparticles (SeNPs) are a potential tumor therapeutic drug and have attracted widespread attention due to their high bioavailability and significant anticancer activity. However, the poor water solubility and degradability of selenium nanoparticles severely limit their application. In this study, spherical selenium nanoparticles with a particle size of approximately 50 nm were prepared by using Sargassum fusiforme polysaccharide (SFPS) as a modifier and Tween-80 as a stabilizer. The results of in vitro experiments showed that Sargassum fusiforme polysaccharide-Tween-80-Selenium nanoparticles (SFPS-Tw-SeNPs) had a significant inhibitory effect on A549 cells, with an IC50 value of 6.14 mu g/mL, and showed antitumor cell migration and invasion ability against A549 cells in scratch assays and cell migration and invasion assays (transwell assays). Western blot experiments showed that SFPS-Tw-SeNPs could inhibit the expression of tumor migration- and invasion -related proteins. These results suggest that SFPS-Tw-SeNPs may be potential tumor therapeutic agents, especially for the treatment of human lung cancer.