文献类型：期刊文献

英文题名：Critical review on bioactive substances from sea food and their health promoting effects

作者：Wijethunga, Thusara[1,2];Wijesekara, Tharuka[1,3];Zhong, Saiyi[4];Xu, Baojun[1]

机构：[1]Beijing Normal Hong Kong Baptist Univ, Dept Life Sci, Food Sci & Technol Program, Zhuhai 519087, Peoples R China;[2]Univ Peradeniya, Fac Agr, Dept Anim Sci, Peradeniya 20400, Sri Lanka;[3]McGill Univ, Fac Agr & Environm Sci, Dept Food Sci & Agr Chem, Quebec City, PQ H9X 3V9, Canada;[4]Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang 524088, Peoples R China

年份：2027

卷号：7

期号：2

起止页码：421

外文期刊名：JOURNAL OF FUTURE FOODS

收录：ESCI(收录号：WOS:001851148900001)、WOS

基金：This project was jointly supported by one open project of Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety (GDPKLAPPS2303) , a project from Shenzhen Science and Technology Program (GJHZ20240218114715029) , and one grant from Beijing Normal-Hong Kong Baptist University, China (UICR0400016-24B) .

语种：英文

外文关键词：Bioactive compounds; Seafood; Marine peptides; Polysaccharides; omega-3 PUFAs; Marine alkaloids; Functional foods; Nutraceuticals

外文摘要：Seafood is a valuable source of bioactive compounds with significant therapeutic potential, contributing to human health through diverse biological activities. These compounds, derived from marine organisms such as fish, crustaceans, mollusks, and algae, exhibit antimicrobial, anti-inflammatory, anticancer, antioxidant, neuroprotective, and immunomodulatory properties. The structural diversity of seafood-derived bioactive compounds, shaped by the unique marine environment, often provides novel pharmacological applications. This review explores key classes of bioactive substances, including peptides, polysaccharides, lipids, alkaloids, polyketides, and terpenoids. Marine-derived peptides, such as antimicrobial peptides from crustaceans, have demonstrated broad-spectrum efficacy against bacterial and viral pathogens. Additionally, bioactive peptides exhibit antihypertensive effects by inhibiting angiotensin-converting enzyme (ACE), contributing to cardiovascular health. Polysaccharides such as chitosan, extracted from crustacean shells, and sulfated glycans, derived from marine algae and invertebrates, have shown significant anticancer activity by inducing apoptosis, modulating immune responses, and inhibiting tumor growth. Marine lipids, particularly omega-3 polyunsaturated fatty acids (PUFAs) like eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), play crucial roles in cardiovascular protection, cognitive function, and inflammation regulation. Furthermore, marine alkaloids, polyketides, and terpenoids exhibit potent anticancer, anti-inflammatory, and neuroprotective properties, with some compounds advancing into clinical trials. The increasing recognition of seafood-derived bioactive compounds highlights their potential in nutraceutical and pharmaceutical applications. However, sustainable harvesting practices, innovative extraction techniques, and further clinical studies are essential for fully unlocking their therapeutic benefits. This review emphasizes the importance of marine biodiversity in drug discovery and the need for continued research to develop functional foods and novel therapeutics addressing global health challenges. (c) 2027 The authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).