文献类型：期刊文献

英文题名：Theragra chalcogramma Hydrolysates, Rich of Fragment Gly-Leu- Pro-Ser-Tyr-Thr, Ameliorate Alcohol-Induced Cognitive Impairment via Attenuating Neuroinflammation and Enhancing Neuronal Plasticity in Sprague-Dawley Rats

作者：Xu, Defeng[1,2];Zhao, Mouming[3]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang, 524088, Peoples R China;[2]Guangdong Prov Engn Technol Res Ctr Marine Food, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang 524088, Peoples R China;[3]South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510640, Peoples R China

年份：2022

卷号：70

期号：39

起止页码：12513

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:000862788100001)、、EI(收录号：20224012842163)、Scopus(收录号：2-s2.0-85139206405)、WOS

基金：Funding This investigation was financially supported by the State Key Research and Development Plan (no. 2017YFD0400200) and the China Postdoctoral Science Foundation (no. 2014M552208) .

语种：英文

外文关键词：alcohol-induced cognitive impairment; neuroinflammation; Theragra chalcogramma hydrolysates; hippocampal histopathology; synaptic plasticity

外文摘要：Chronic alcohol abuse induces the cognitive deficits and is associated with low-grade inflammation and neurodegeneration. Currently, by virtue of the immunomodulatory and neuroprotective properties, nutrients represent a promising strategy to attenuate cognitive impairments. We previously prepared the hydrolysates from Theragra chalcogramma skin (TCH), and this study aims to evaluate the neuroprotection of TCH on alcohol-induced cognitive impairment (AICI) and to elucidate the associated mechanism. Behavioral results showed that TCH effectively ameliorated AICI and this amelioration was highly associated with the decrease of IL-1 beta and the increase of BDNF, CREB, and PSD95 in AICI rats (P < 0.05). Furthermore, TCH restored the histopathological impairment in hippocampus by reactivating extracellular signal-regulated kinase and suppressing Caspase-3 apoptosis signal pathways and modulating the abnormality of neurotransmitters acetylcholine and gamma-aminobutyric acid(P < 0.05 or 0.01). Therefore, TCH exhibits potent attenuation of neuroinflammation and represents a potential ingredient for prevention of AICI.