文献类型：期刊文献

英文题名：Renoprotective Effect of Coix lachryma-jobi L. Seed Polysaccharides in Adenine-Induced Chronic Renal Failure by Blocking Gut Urea Metabolism

作者：Yin, Hongmei[1]; Liao, Wanjun[1]; Huang, Yilian[1]; Hong, Qiang[1]; Zhang, Na[1]; Shi, Xiaodan[1]; Tu, Zongcai[1,2]; Wang, Hui[3]; Xie, Zuohua[4]; Yuan, Tao[1]

机构：[1] Jiangxi Province Key Laboratory of Natural and Biomimetic Drugs Research, College of Pharmacy, Jiangxi Normal University, Jiangxi, Nanchang, China; [2] State Key Laboratory of Food Science and Resources, Nanchang University, Jiangxi, Nanchang, China; [3] College of Food Science and Technology, Guangdong Ocean University, Guangdong, Zhanjiang, China; [4] Jiangxi Deshang Pharmaceutical Co., Ltd., Jiangxi, Zhangshu, China

年份：2026

卷号：7

期号：1

外文期刊名：Food Frontiers

收录：EI(收录号：20254319375162)、Scopus(收录号：2-s2.0-105019191725)

语种：英文

外文关键词：Agriculture - Body fluids - Creatinine - Food safety - Mammals - Metabolism - Nutrition - Toxic materials

外文摘要：Dietary soluble fiber may alleviate renal damage in chronic kidney disease (CKD) by promoting intestinal urea excretion, though the underlying mechanisms remain unclear. This study investigated the digestion, fermentation, and renoprotective effects of Coix lachryma-jobi L. seed polysaccharides (CP) using in vitro systems and adenine-induced CKD mice. CP resisted gastric and small intestinal digestion but was effectively fermented by human gut microbiota, exhibiting?effective urease inhibitory activity and reducing ammonia production in vitro. In CKD mice, CP treatment ameliorated renal histopathology, reduced serum creatinine, phosphorus, calcium, and fecal p-cresol, indole, while increasing urinary and fecal urea excretion and decreasing fecal ammonia. CP reshaped the gut microbiota, reducing Parabacteroides, Anaeroplasma, and other genera linked to amino acid metabolism (all p ? 2025 The Author(s). Food Frontiers published by Nanchang University, Northwest University, Jiangsu University, Fujian Agriculture and Forestry University, International Association of Dietetic Nutrition and Safety and John Wiley & Sons Australia, Ltd.