文献类型：期刊文献

中文题名：高温高压处理隐蔽态T-2毒素对小鼠毒性的影响

英文题名：Effects of high temperature and high pressure on the toxicity induced by modified T-2 toxins(mT-2s)in mice

作者：宋颖慧[1];邱妹[1];孙力军[1];王雅玲[1];周道志[1];叶林[1];邓旗[1];房志家[1]

机构：[1]广东海洋大学,食品科技学院,广东省水产品加工与安全重点实验室,广东普通高等学校水产品深加工重点实验室,湛江524088

年份：2022

卷号：39

期号：2

起止页码：58

中文期刊名：生物学杂志

外文期刊名：Journal of Biology

收录：CSTPCD、、北大核心、CSCD、北大核心2020、CSCD_E2021_2022

基金：国家自然科学基金面上项目(31871898);广东省现代农业产业技术体系创新团队建设专项资金项目(2020KJ149,2020KJ151)。

语种：中文

中文关键词：高温高压;隐蔽态T-2毒素;小鼠;免疫器官指数;微核率

外文关键词：high temperature and high pressure;modified T-2 toxins;mice;immune organ index;micronucleus rate

中文摘要：为探明高温高压处理隐蔽态T-2毒素(mT-2s)诱导的小鼠毒效应,将40只小鼠随机分为mT-2s组(未处理组)、高温高压处理mT-2s组(处理组)、阴性对照组和阳性对照组,连续灌胃7 d,检测小鼠的免疫器官指数、骨髓微核率、精子畸形率、血清生化指标并分析其变化特征。结果表明:与未处理组相比,高温高压处理组小鼠的免疫器官指数、骨髓微核率、精子畸形率和血清生化指标差异显著(P<0.05);与阳性对照组相比,高温高压处理组小鼠的免疫器官指数、骨髓微核率、精子畸形率和血清生化指标差异不显著(P>0.05)。高温高压处理能够导致mT-2s释放前体毒素,进而增强其毒效应,警示动植物源性食品中mT-2s残留引起的食品安全问题不容忽视。

外文摘要：High temperature and high pressure technology is a technology that eliminates harmful microorganisms in food to achieve commercial sterile conditions without adding harmful substances such as preservatives.In order to investigate the toxic effect of the modified T-2 toxin(mT-2s)in mice induced by high temperature and high pressure treatment,through the mouse exposure experiment,mT-2s was treated under high temperature and high pressure,forty mice were randomly divided into mT-2s group(untreated),mT-2s group treated with high temperature and high pressure,negative control and positive control group,which were administered by oral to mice for 7 days.The immune organ index,bone marrow micronucleus rate,sperm deformity rate and serum biochemical indexes of mice were detected to analyze its change characteristics.The results showed that compared with that of the untreated group,the immune organ index,bone marrow micronucleus rate,sperm malformation rate and serum biochemical indexes of the mice treated with high temperature and high pressure were significantly different(P<0.05);compared with that of the positive control group,the immune organ index,bone marrow micronucleus rate,sperm malformation rate and serum biochemical indexes of mice treated with high temperature and high pressure were not significantly different(P>0.05).In summary,high temperature and high pressure treatment could cause mT-2s to release precursor toxins,thereby enhancing its toxic effect,warning that food safety issues caused by mT-2s residues in foods of animal and plant origin cannot be ignored.