文献类型：期刊文献

英文题名：Fluorescent carbon dots loading nitric oxide for bacterial labeling and killing

作者：Chen, Ziheng[1];Peng, Song[2,3];Liu, Shixin[1];Li, Chengpeng[4];Cai, Xiang[5];Ma, Dong[1,6];Zhang, Wu[2,3]

机构：[1]Jinan Univ, Guangdong Prov Engn & Technol Res Ctr Drug Carrie, Key Lab Biomat, Dept Biomed Engn,Guangdong Higher Educ Inst, Guangzhou, Peoples R China;[2]Jinan Univ, Sch Stomatol, Guangzhou, Peoples R China;[3]Jinan Univ, Affiliated Hosp 1, Guangzhou, Peoples R China;[4]Guangdong Ocean Univ, Sch Chem & Environm Sci, Zhanjiang, Peoples R China;[5]Guangdong Polytech, Dept Light Chem Engn, Foshan, Peoples R China;[6]Jinan Univ, MOE Key Lab Tumor Mol Biol, Guangzhou, Peoples R China

年份：2022

卷号：71

期号：15

起止页码：1188

外文期刊名：INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS

收录：SCI-EXPANDED(收录号：WOS:000684094600001)、、EI(收录号：20213310760612)、Scopus(收录号：2-s2.0-85112141032)、WOS

基金：Ziheng Chen and Song Peng contributed equally to this work. This work was financially supported by the Science and Technology Program of Guangzhou, China under Grant [No. 201904010145]; Fundamental Research Funds for the Central Universities under Grant [21620102 and 21620455]; and GDHVPS (2017).

语种：英文

外文关键词：Antibacterial; bacterial imaging; carbon dots; nitric oxide

外文摘要：Bacterial infection is a serious threat to human health. In this work, carbon dots (CDs) based on the polyethyleneimine (PEI) was prepared by hydrothermal carbonization method and then reacted with nitric oxide (NO) to form the NO-loaded CDs (CD-PEI/NONOate). CD-PEI/NONOate showed a high NO payload and outstanding fluorescence characteristics. It was found that CD-PEI/NONOate could inhibit the growth of Gram-negative bacteria Pseudomonas aeruginosa by more than 99%. Moreover, CD-PEI/NONOate showed no cytotoxicity to 3T3 cells at concentrations used in vitro. These results indicated that the prepared CD-PEI/NONOate has a potential application in the diagnosis and treatment of bacterial infection.