文献类型：期刊文献

英文题名：Antioxidant, anticoagulant and thrombolytic properties of SIP-IV, a sulfated polysaccharide from Sepia esculenta ink, and its derivatives

作者：Li, Fangping[1];Lin, Zhen[1];Wu, Yulian[1];Luo, Ping[1];Wu, Jiayi[1];Liu, Huazhong[1]

机构：[1]Guangdong Ocean Univ, Coll Chem & Environm Sci, Zhanjiang 524088, Peoples R China

年份：2022

卷号：49

外文期刊名：FOOD BIOSCIENCE

收录：SCI-EXPANDED(收录号：WOS:000863320200003)、、Scopus(收录号：2-s2.0-85138538236)、WOS

基金：This work was supported by grants from Guangdong Basic and Applied Basic Research Foundation (2022A1515012091) , the Project of Application -Based Talent Training Course from Guangdong Ocean University (570319017, 571119165) , and Postgraduate Education Innovation Program of Guangdong Ocean University (521005022, 040502122103) .

语种：英文

外文关键词：SIP -IV derivatives; Cyclophosphamide; Antioxidant; Anticoagulant; Thrombolysis; Mice

外文摘要：Carboxymethylated, phosphorylated and sulfated derivatives of SIP-IV, a polysaccharide derived from Sepia esculenta ink, were prepared and their antioxidant, anticoagulant and thrombolytic properties were evaluated. Data showed that sulfation and phosphorylation modification improved antioxidant activity of SIP-IV, but carboxymethylation impaired the property. In vitro data showed that SIP-IV and its three modified derivatives could significantly prolong activated partial thrombin time (APTT), prothrombin time (PT) and thrombin time (TT), and also exhibited thrombolysis activity. In vivo, these polymers alleviated chemotherapy-induced blood hypercoagulation by reversing abnormal levels of coagulation factors II and X, and antithrombin III in plasma, resulting in prolonged bleeding time. Moreover, the polysaccharides play an antagonistic role against chemotherapy-mediated liver oxidative stress. Sulfate-modified polysaccharide (S-SIP-IV) has the best anticoagulant, thrombolytic and antioxidant effects.