文献类型：期刊文献

英文题名：Acylated anthocyanin inhibited the formation of heterocyclic amines in hybrid chemical model system and its underlying mechanism

作者：Teng, Hui[1];Mi, Yani[2];Deng, Hongting[1];He, Yuanju[1];Wang, Shunxin[1];Ai, Chao[1];Cao, Hui[1];Chen, Lei[1]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Guangdong Prov Engn Lab Marine Biol Prod,Guangdong, Zhanjiang 524088, Peoples R China;[2]Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China

年份：2023

卷号：17

外文期刊名：FOOD CHEMISTRY-X

收录：SCI-EXPANDED(收录号：WOS:001029062700001)、、EI(收录号：20230213377290)、Scopus(收录号：2-s2.0-85145980194)、WOS

基金：This work is supported by the National Natural Science Foundation of China (NSFC, Grant No. 32072209, 32061160477) , the Natural Science Foundation of Guangdong Province (2022A1515010694) , China Postdoctoral Science Foundation Funded Project (2020M682073) , the Innovative Team Program of High Education of Guangdong Province (2021KCXTD021) .

语种：英文

外文关键词：Acylated anthocyanin; Chemical models heterocyclic amine; Inhibition; Enzymatic acylation

外文摘要：Enzymatic acylation was employed to synthesize acylated anthocyanin, and a hybrid chemical model system was used for the formation of heterocyclic amines. And the inhibition effect and underline mechanism were investigated by analyzing the variations in important precursors and intermediates. Results confirmed that cyanidin-3(6-cinnamoyl) -glycosidase (C3(6C)G) with a purity of 98.9% was obtained. HPLC identified seven types of heterocyclic amines (IQ, MeIQx, 4, 8-DimeiqX, Norharman, Harman, PhIP, and A & alpha;C) generated in the chemical model. (C3(6C)G) showed a good concentration-dependent manner for the inhibition effect on most HCAs except for MeIQx and PhIP. It also suppressed the glucose content, showed a dose-dependent manner in creatine/ creatinine inhibition, and could scavenge formaldehyde, acetaldehyde, and phenylacetaldehyde. Two potential pathways might be involved: 1. by inhibiting the content of precursors (glucose and creatinine), competing with the formation of amino acids, to suppress HCAs generation; 2 through the removal of reactive carbonyl, reducing its reaction with creatinine.