文献类型：期刊文献

英文题名：Squid ink polysaccharide prevents chemotherapy induced injury in the testes of reproducing mice

作者：Luo, Ping[1];Liu, Hua-Zhong[1];Le, Xiao-Yan[1];Du, Hui[2];Kang, Xin-Huang[1]

机构：[1]Guangdong Ocean Univ, Coll Chem & Environm, Zhanjiang, Guangdong, Peoples R China;[2]Guangdong Ocean Univ, Biochem Ctr, Zhanjiang, Guangdong, Peoples R China

年份：2018

卷号：31

期号：1

起止页码：25

外文期刊名：PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES

收录：SCI-EXPANDED(收录号：WOS:000422614800004)、、Scopus(收录号：2-s2.0-85039868871)、WOS

基金：The work was supported by the National Natural Science Foundation of China (31171667) and by the Natural Science Foundation of Guangdong Province, China (2016A030313753).

语种：英文

外文关键词：Squid ink polysaccharide (SIP); cyclophosphamide; sperm; reproduction; mice

外文摘要：The present study was conducted to investigate the preventive effects of squid ink polysaccharides (SIP) on the damage of sperm and reproduction induced by cyclophosphamide that is most commonly used for treating clinically cancers. Male Kunming mice exposed to cyclophosphamide were administered with SIP and were sacrificed to determine sperm parameters, testicular antioxidant ability and reproductive capacity. Data indicated that cyclophosphamide caused obvious changes in mice such as significant reduction (P<0.01) of glutathione reductase activity (GR), vitamin C (Vc) content and total antioxidant capacity (T-AOC) in the testes, as well as elevation (P<0.01) of abnormal rates of sperm and fetus, and a decrease in the total fetal count and average fetal count (P<0.01), were totally alleviated by SIP. From these findings it can be concluded that SIP decreases chemotherapeutic damage to sperm and reproduction in mice induced by cyclophosphamide.