文献类型：期刊文献

英文题名：2-Pyridinecarboxaldehyde-Modified Chitosan-Silver Complexes: Optimized Preparation, Characterization, and Antibacterial Activity

作者：Zhang, Zhaoyu[1];Zhao, Yurong[1];Hu, Zhang[1];Si, Zhenyu[1];Yang, Ziming[2]

机构：[1]Guangdong Ocean Univ, Fac Chem & Environm Sci, Zhanjiang 524088, Peoples R China;[2]Chinese Acad Trop Agr Sci, South Subtrop Crop Res Inst, Zhanjiang 524001, Peoples R China

年份：2023

卷号：28

期号：19

外文期刊名：MOLECULES

收录：SCI-EXPANDED(收录号：WOS:001086357100001)、、Scopus(收录号：2-s2.0-85173842430)、WOS

基金：Key Projects of Colleges and Universities in Guangdong Province (2022ZDZX2027), Guangdong Ocean University Undergraduate Innovation Team Project (CXTD2021020), and the National Key Research and Development Program of China (2020YFD0901101).

语种：英文

外文关键词：modified chitosan; silver; complex; response surface methodology; antibacterial

外文摘要：The widespread prevalence of infectious bacteria is one of the greatest threats to public health, and consequently, there is an urgent need for efficient and broad-spectrum antibacterial materials that are antibiotic-free. In this study, 2-pyridinecarboxaldehyde (PCA) was grafted onto chitosan (CS) and the modified CS coordinated with silver ions to prepare PCA-CS-Ag complexes with antibacterial activity. To obtain complexes with a high silver content, the preparation process was optimized using single-factor experiments and response surface methodology. Under the optimal preparation conditions (an additional amount of silver nitrate (58 mg), a solution pH of 3.9, and a reaction temperature of 69 C-degrees), the silver content of the PCA-CS-Ag complex reached 13.27 mg/g. The structure of the PCA-CS-Ag complex was subsequently verified using ultraviolet-visible spectroscopy, Fourier-transform infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, and thermogravimetric analysis. Furthermore, three possible complexation modes of the PCA-CS-Ag complex were proposed using molecular mechanics calculations. The results of the antibacterial assay in vitro showed that the PCA-CS-Ag complex exhibited strong antibacterial activity against both Gram-positive and Gram-negative bacteria, exerting the synergistic antibacterial effect of modified chitosan and silver ions. Therefore, the PCA-CS-Ag complex is expected to be developed as an effective antibacterial material with promising applications in food films, packaging, medical dressings, and other fields.