文献类型：期刊文献

英文题名：Preparation and characterization of amphiphilic chitosan/iodine composite film as antimicrobial material

作者：Zhang, Lingyu[1];Zhang, Zhaoyu[1];Li, Chengpeng[1];Hu, Zhang[1];Liang, Youling[1];Yang, Ziming[2];Cheng, Yu[1];Huang, Dejian[1]

机构：[1]Guangdong Ocean Univ, Fac Chem & Environm Sci, Zhanjiang 524088, Peoples R China;[2]Chinese Acad Trop Agr Sci, South Subtrop Crop Res Inst, Zhanjiang 524001, Peoples R China

年份：2022

卷号：222

起止页码：2426

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：SCI-EXPANDED(收录号：WOS:000892288700003)、、EI(收录号：20241015684204)、Scopus(收录号：2-s2.0-85139730611)、WOS

基金：The authors acknowledge the financial support of Project of Science and Technology Plan of Zhanjiang (2020A01026), Key Projects of Colleges and Universities in Guangdong Province (2022ZDZX2027), Guangdong Ocean University Undergraduate Innovation Team Project (CXTD2021020), and National Key Research and Development Program of China (2020YFD0901101) for this work.

语种：英文

外文关键词：Amphiphilic chitosan; Iodine; Film; Antibacterial

外文摘要：The composite film of amphiphilic chitosan/iodine, poly(aminoethyl) chitosan citronellal Schiff base iodine (PACSC-I), was prepared, and characterized by SEM, AFM, FTIR, 1H NMR and XRD. The physicochemical properties of the film including hydrophilicity, water absorption, mechanical, thermal degradation, iodine release and antibacterial properties were tested, and the cytocompatibility evaluation of the composite film was also performed. The results showed that PACSC-I was successfully prepared with good hydrophilicity (water contact angle 47.34 degrees), water absorption capacity (water absorption ratio 229.55 %), elasticity (elongation at break 6.72 %) and thermal stability. The composite film had a controlled release effect on iodine, reaching a maximum released concentration of 8.84 x 10-4 mol/L. PACSC-I exerted a synergistic antibacterial effect with strong antibacterial activities. Cell viability and apoptosis assays showed that PACSC-I had good biocompatibility towards HaCaT cells. Therefore, the PACSC-I film had promising applications in the medical field as antibacterial material.