文献类型：期刊文献

中文题名：对虾中隐蔽态T-2毒素残留对雄性小鼠生长发育的影响及其遗传毒性效应

英文题名：Effect of Masked T-2 Toxin in Litopenaeus vannamei on Growth and Development and Cytogenetic Toxicity of Male Mice

作者：王小博[1,2];邱妹[1];王雅玲[1];孙力军[1];徐德峰[1];刘颖[1];叶日英[1];励建荣[3]

机构：[1]广东海洋大学食品科技学院广东省水产品加工与安全重点实验室广东普通高等学校水产品深加工重点实验室;[2]佛山职业技术学院;[3]渤海大学辽宁省食品安全重点实验室

年份：2018

卷号：18

期号：8

起止页码：48

中文期刊名：中国食品学报

外文期刊名：Journal of Chinese Institute of Food Science and Technology

收录：CSTPCD、、EI(收录号：20183905870816)、北大核心2017、Scopus、CSCD2017_2018、北大核心、CSCD

基金：国家自然科学基金面上项目(31171634;31371777);广东省渔业局项目(粤财农[2015]115号);广东省科技计划项目(2014B020205006);佛山市科技创新平台(食品中有害物质快速检测技术科技创新研究与应用平台)项目(2015AG10023)

语种：中文

中文关键词：T-2毒素;隐蔽态;精子畸形率;微核率

外文关键词：T-2 toxin;masked;sperm deformity rate;micronucleus rate

中文摘要：为探明对虾中隐蔽态T-2染毒对小鼠生长发育及遗传方面的毒性效应,采用定期递增剂量法进行20 d蓄积染毒实验,以对虾的虾头和肌肉匀浆液灌胃小鼠,连续7 d,记录小鼠器官指数、精子致畸率、微核率,分析对虾中T-2及隐蔽态残留物对小鼠的毒害作用。结果表明,低剂量染毒对虾对小鼠没有影响,高剂量组(12.2 mg/kg)染毒对虾引起小鼠增重率和器官系数下降,精子畸形率及微核率均显著高于对照组(P<0.05);随着染毒剂量的增加,精子畸形率及微核率呈上升趋势。染毒对虾中存在隐蔽态的T-2毒素,对小鼠有一定的遗传毒性,虾头中隐蔽态T-2毒素的含量高于肌肉中的,并与染毒剂量呈正相关。

外文摘要：Proven the toxic effect of masked T-2 toxin in Litopenaeus vannamei on growth and development and ge- netic of male mice. Mice, with head and muscle homogenates of the shrimps which were conducted the experiment of 20 d accumulation toxicity with Does-periodic-increased methods through tube feeding for 7 d. Then recording the organ index, spermatozoa deformity and micronucleus of marrow cell were measured. Analysis of the toxic effects of T-2 and the hidden residues in the shrimp on mice. The results showed that low doses T-2 infected shrimp has no effect on mice. However, high dose T-2 infected shrimp caused decreasing of organ index. Sperm deformity rate and micronucleus rate were significantly higher than that of the control group （P〈0.05）; With the increase of the exposure dose, the ab- normal rate of sperm and the rate of micronucleus increased. Research shows T-2 in feed could transformed into masked T-2 toxins （mT-2s） by shrimp after ingesting, T-2 was exposed to a certain genetic toxicity, and the contents of the masked T-2 in the head were higher than that in the muscle; which was positively correlated with the exposure dose.