文献类型：期刊文献

中文题名：肉桂多酚清除自由基及抑制α-葡萄糖苷酶活性的能力

英文题名：The Abilities of Cinnamon Polyphenols to Scavenge Free Radicals and Inhibitα-Glucosidase

作者：龙晓珊[1,2];廖森泰[1,3];刘书成[2];刘凡[1,3];黎尔纳[1];庞道睿[1,3];穆利霞[1];王卫飞[1];邹宇晓[1,3]

机构：[1]广东省农业科学院蚕业与农产品加工研究所,农业农村部功能食品重点实验室,广东省农产品加工重点实验室,广东广州510610;[2]广东海洋大学食品科技学院,广东省水产品加工与安全重点实验室,广东省海洋食品工程技术研发中心,广东省海洋生物制品工程重点实验室,广东湛江524088;[3]岭南现代农业科学与技术广东省实验室茂名分中心,广东茂名525000

年份：2021

卷号：37

期号：8

起止页码：119

中文期刊名：现代食品科技

外文期刊名：Modern Food Science and Technology

收录：CSTPCD、、Scopus、北大核心、北大核心2020

基金：国家自然科学基金项目(31801525);高水平农科院建设科学创新战略专项基金(R2018QD-082,R2018PY-JG001);广东省农业科学院院长基金(201805B);南药专家工作站(2020工作站20-14)。

语种：中文

中文关键词：肉桂;多酚;自由基;α-葡萄糖苷酶;抗氧化

外文关键词：cinnamon;polyphenol;free radical;α-glucosidase;antioxidant

中文摘要：本研究主旨是探讨肉桂多酚的体外抗氧化和α-葡萄糖苷酶抑制能力,为肉桂多酚的开发利用提供理论基础。通过福林酚法测定肉桂多酚的总酚含量,采用试剂盒以及有机试剂检测肉桂多酚清除ABTS+、Fe3+、DPPH、OH-等自由基的能力以及对α-葡萄糖苷酶活性的抑制效果。结果表明,肉桂多酚的含量为64.43 mg/g(干重),对ABTS+、Fe3+、DPPH、OH-等自由基具有明显的清除能力,其IC50值(半抑制率浓度)分别为0.71、0.27、0.18、0.97 mg/mL,对以上四种自由基的清除能力由强到弱依次为DPPH>Fe3+>ABTS+>OH-,且存在剂量依赖性,自由基的清除能力随着样品质量浓度的增加而提高。肉桂多酚对α-葡萄糖苷酶具有显著的抑制能力,其IC50值为0.048 mg/mL,同样存在剂量依赖性,且抑制效果显著高于阿卡波糖对照。因此,肉桂多酚对ABTS+、Fe3+、DPPH、OH-等自由基具有明显的清除能力,对α-葡萄糖苷酶具有显著的抑制能力。

外文摘要：The main aim of this study to investigate the in vitro antioxidant activity and ability to inhibitα-glucosidase of the cinnamon polyphenols,to provide theoretical basis for their development and applications.The total phenolic contents of the cinnamon polyphenols were determined by the folin-phenol method.The ABTS+,Fe3+,DPPH·and OH-scavenging abilities and the inhibition ofα-glucosidase activity of the cinnamon polyphenols were detected using the kits and organic reagents.The results showed that the content of cinnamon polyphenols was 64.43 mg/g(dry weight),and significant scavenging abilities towards ABTS+,Fe3+,DPPH·and OH-were detected with the IC50 values(half inhibitory concentration)being 0.71,0.27,0.18 and 0.97 mg/mL,respectively).The scavenging abilities of the cinnamon polyphenols towards the above-mentioned free radicals were in the order of DPPH·>Fe3+>ABTS+>OH-,and exhibited in a dose-dependent manner(scavenging ability increased with an elevated mass concentration).The cinnamon polyphenols had a significant inhibitory effect onα-glucosidase in a dose-dependent manner,with an IC50 value as 0.048 mg/mL,and such inhibition was significantly greater than that of acarbose.Therefore,the cinnamon polyphenols possess significant abilities to scavenge ABTS+,Fe3+,DPPH·,OH-radicals,and inhibit the activity ofα-glucosidase.