文献类型：期刊文献

英文题名：Myostatin downregulates the expression of basic fibroblast growth factor gene in HeLa cells

作者：Liu, H. Z.[2];Luo, P.[3];Chen, S. H.[2];Shang, J. H.[1]

机构：[1]Chinese Acad Agr Sci, Buffalo Res Inst, Guangxi Key Lab Buffalo Genet Reprod & Breeding, Nanning 530001, Peoples R China;[2]Guangdong Ocean Univ, Modern Biochem Ctr, Zhanjiang, Peoples R China;[3]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang, Peoples R China

年份：2012

卷号：113

期号：8

起止页码：471

外文期刊名：BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY

收录：SCI-EXPANDED(收录号：WOS:000307990400003)、、Scopus(收录号：2-s2.0-84866284191)、WOS

基金：The authors thank grants from Natural Science Foundation of Guangxi Zhuang Autonomous Region of China (0991011) and Natural Science Foundation of Guangdong Ocean University for financial support.

语种：英文

外文关键词：myostatin; basic fibroblast growth factor; HeLa cells

外文摘要：Basic fibroblast growth factor (bFGF or FGF-2), a potent tumorigenic cytokine, improves cells proliferation and angiogenesis in tumor and also plays vital roles in tumor growth, metastasis as well as prognosis. Screening and application of effective cytokines against bFGF tumorigenic activity would be helpful to oncologic therapy. Myostatin, a member of transforming growth factor 13 superfamily, recently showed an antitumor activity and was reported to induce He La cells apoptosis through mitochondrion pathway. The above data raised our assumption that expression level of endogenous bFGF gene may be suppressed by exogenous myostatin in myostatin-treated He La cells. To test the hypothesis, myostatin was employed to stimulate He La cells and expressional level of endogenous bFGF gene in He La cells was detected with real-time RT-PCR and ELISA. Results of the suppressed expression level of bFGF gene in He la cells implied that myostatin may be regarded as an effective cytokine against bFGF to treat certain cancers (Fig. 3, Ref. 26). Full Text in PDF www.elis.sk.