文献类型：期刊文献

英文题名：Sodium butyrate alleviates heat stress-induced damage to morphology, anti-oxidant status, inflammatory response and barrier integrity in jejunum of broilers

作者：Ruixia, Lan[1];Wu, Fan[1];Wang, Yucheng[1];Yin, Fuquan[1]

机构：[1]Guangdong Ocean Univ, Coll Coastal Agr Sci, Dept Anim Sci, Zhanjiang, Peoples R China

年份：2024

卷号：23

期号：1

起止页码：215

外文期刊名：ITALIAN JOURNAL OF ANIMAL SCIENCE

收录：SCI-EXPANDED(收录号：WOS:001155431900001)、、Scopus(收录号：2-s2.0-85183769199)、WOS

基金：This work was supported by the program for scientific research start-up funds of Guangdong Ocean University (101402/R18005).

语种：英文

外文关键词：Sodium butyrate; anti-oxidant capacity; inflammatory response; intestinal barrier function; heat-stressed broilers

外文摘要：To evaluate the protective effects of sodium butyrate (SB) on intestinal morphology, anti-oxidant status, inflammatory response and barrier integrity in male broilers under heat stress. A total of 180 21-d-old male Arbour Acres broilers with similar body weight were used for this 21-d experiment. Broilers were randomly allocated to three groups: CON group, basal diet and raised under 24 degrees C; HS group, basal diet and raised under heat stress condition (34 degrees C from 10:00 to 18:00 and 24 degrees C for the rest time); HS-SB group, basal diet with 1200 mg/kg SB and raised under heat stress condition. Compared to the HS group, SB supplementation increased average daily gain (ADG), villus height: crypt depth ratio (VH: CD), VH, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) activity, and interleukin-10 (IL-10) level, decreased feed conversion ratio (FCR), CD, reactive oxygen species (ROS), IL-1 beta and tumour necrosis factor-alpha (TNF-alpha) level, up-regulated the mRNA expression of nuclear factor erythroid 2-related factor 2, haem oxygenase 1, GSH 1 (GPX1), SOD and CAT, down-regulated the mRNA expression of toll-like receptor 4 (TLR4), nuclear transcription factors, IL-1 beta, and TNF-alpha in jejunum of heat-stressed broilers. Furthermore, SB supplementation up-regulated the mRNA expression of occluding, claudin-1 and zona occludens-1 (ZO-1) in jejunum of heat-stressed broilers, accompanied with decreasing serum endotoxin and D-lactic acid concentration, and diamine oxidase (DAO) activity. There results suggested that SB supplementation could alleviate heat stress-induced jejunal tight junction structure dysfunction by up-regulated the expression of occluding, claudin-1 and ZO-1, presumably through alleviating oxidative stress and inflammatory response.HIGHLIGHTSSodium butyrate alleviated heat stress-induced jejunal morphology damage.Sodium butyrate alleviated heat stress-induced jejunal oxidative damage.Sodium butyrate alleviated heat stress-induced jejunal inflammatory response.Sodium butyrate alleviated heat stress-induced tight junction structure dysfunction.