文献类型：期刊文献

英文题名：The anti-fatigue effect of the Auxis thazard oligopeptide via modulation of the AMPK/PGC-1α pathway in mice

作者：Qu, Yushan[1];Ji, Hongwu[1,2,3,4,5];Song, Wenkui[1];Peng, Shuo[1];Zhan, Suhong[1];Wei, Liuyi[1];Chen, Ming[1];Zhang, Di[1];Liu, Shucheng[1,2,3,4,5,6]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524088, Peoples R China;[2]Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang 524088, Peoples R China;[3]Guangdong Prov Engn Lab Marine Biol Prod, Zhanjiang 524088, Peoples R China;[4]Guangdong Prov Engn Technol Res Ctr Marine Food, Zhanjiang 524088, Peoples R China;[5]Guangdong Higher Educ Inst, Key Lab Adv Proc Aquat Prod, Zhanjiang 524088, Peoples R China;[6]Dalian Polytech Univ, Collaborat Innovat Ctr Seafood Deep Proc, Dalian 116034, Peoples R China

年份：2022

卷号：13

期号：3

起止页码：1641

外文期刊名：FOOD & FUNCTION

收录：SCI-EXPANDED(收录号：WOS:000746911600001)、、EI(收录号：20220711651111)、Scopus(收录号：2-s2.0-85124438185)、WOS

基金：This work was co-supported by the National Key Research and Development Program (2019YFD0902004) and the Guangdong Innovation Team of Seafood Green Processing Technology (2019KCXTD011).

语种：英文

外文摘要：The Auxis thazard oligopeptide (ATO) was obtained by papain digestion and ultrafiltration membrane separation, and its anti-fatigue effects and mechanisms were evaluated using animal experiments on Kunming mice. Compared with the negative control group, the ATO extended the time to exhaustion in mice in a forced swim test by 0.81-1.62 times. Liver glycogen levels were significantly increased by 0.6-1.63 times and muscle glycogen levels were increased by 9.52-10.02%; the levels of lactic acid (16.46-17.21%) and urea nitrogen (34.88-41.91%) decreased. The ATO also increased antioxidant activity, reduced malondialdehyde levels (18.00-35.79%) in the liver and myocardium, and increased the gene and protein expression of AMPK and PGC-1 alpha in fatigued mice. These results indicate that the ATO exerts an anti-fatigue effect via improving energy metabolism and decreasing oxidative stress.