详细信息
文献类型:期刊文献
中文题名:表没食子儿茶素没食子酸酯固体粉末的稳定性考察
英文题名:Stability of Epigallocatechin Gallate Solid Powder
作者:郭震[1];林坚涛[2];黄韧[1];廖艳[3];王敏[1];沈佳娜[1];吴玉娥[1]
机构:[1]广东省实验动物监测所;[2]广东医学院药理教研室;[3]广东海洋大学分析测试中心
年份:2007
卷号:18
期号:25
起止页码:1973
中文期刊名:中国药房
外文期刊名:China Pharmacy
收录:CSTPCD、、北大核心2004、CSCD_E2011_2012、北大核心、CSCD
基金:广东省中医药局科研项目(2060038)
语种:中文
中文关键词:表没食子儿荼素没食子酸酯;固体粉末;高效液相色谱法;稳定性
外文关键词:Epigallocatechin gallate ; Solid powder ; HPLC; Stability
中文摘要:目的:考察表没食子儿茶素没食子酸酯(EGCG)固体粉末的稳定性。方法:采用高效液相色谱法测定含量,按照《中国药典》相关规定对影响EGCG稳定性的因素进行研究。结果:EGCG检测浓度的线性范围为7.76~77.6μg·mL-1(r=0.9999);平均回收率为101.29%(RSD=0.76%);在强光、高温、高湿条件下,EGCG粉末颜色有不同程度的变化,但含量均无明显变化,也未见新的降解物质产生。结论:EGCG固体粉末的稳定性较好。
外文摘要:OBJECTIVE: To investigate the stability of epigallocatechin gallate (EGCG) powder. METHODS: The content of the sample was determined by HPLC, and the factors affecting the stability of EGCG were studied according to the related guideline stated in China Pharmacopeia, RESULTS: The linear range of EGCG was 7.76- 77.6μg · mL^-2(r = 0.999 9), with average recovery at 101.29% (RSD= 0.76%) Exposed to strong illumination, high temperature and high humidity, the color of EGCG powder suffered variant degree of change, but its content experienced no marked change, and no new degraded substances was noted. CONCLUSION: EGCG powder had a sound stability.
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