文献类型：期刊文献

英文题名：Heterophyllin B, a cyclopeptide from Pseudostellaria heterophylla, improves memory via immunomodulation and neurite regeneration in i.c.v. Aβ-induced mice

作者：Deng, Jiahang[1];Feng, Xinyue[1];Zhou, Longjian[1,2];He, Chuantong[1];Li, Huilin[3];Xia, Juan[1];Ge, Yuewei[3];Zhao, Yuntao[1,2];Song, Cai[1,2];Chen, Lei[1,2];Yang, Zhiyou[1,2]

机构：[1]Guangdong Ocean Univ, Key Lab Adv Proc Aquat Prod, Coll Food Sci & Technol, Guangdong Prov Engn Technol Res Ctr Seafood,Guangd, Zhanjiang 524088, Peoples R China;[2]Dalian Polytech Univ, Collaborat Innovat Ctr Seafood Deep Proc, Dalian 116034, Peoples R China;[3]Guangdong Pharmaceut Univ, Key Lab Digital Qual Evaluat Chinese Mat Med, State Adm TCM, Guangzhou 510006, Peoples R China

年份：2022

卷号：158

外文期刊名：FOOD RESEARCH INTERNATIONAL

收录：SCI-EXPANDED(收录号：WOS:000823246600008)、、EI(收录号：20222612294570)、Scopus(收录号：2-s2.0-85132920696)、WOS

基金：This research was funded by the Natural Science Foundation of Guangdong Province of China (grant number 2022A1515011419 and 2020A1515010779) , National Natural Science Foundation of China (grant number 81803753) , Scientific Research Foundation of Guang-dong Ocean University (grant number R19035) , and the Innovative Team Program of High Education of Guangdong Province (2021KCXTD021) .

语种：英文

外文关键词：Pseudostellaria heterophylla; Heterophyllin B; Neurite regeneration; Memory retrieval

外文摘要：Pseudostellaria heterophylla, has historically been used as medicine food homology plant for thousand years in China. Our previous studies had indicated that daily intake of Pseudostellaria heterophylla extract enhanced cognitive memory. Herein, heterophyllin B (HET-B), a brain permeable cyclopeptide from Pseudostellaria heterophylla was determined, and the molecular mechanism underlying its memory improvement effects was investigated. Pseudostellaria heterophylla extract as well as HET-B reversed A beta 25-35-induced axonal atrophy and neuronal apoptosis in cultured cortical neurons of mice. HET-B could enhance memory retrieval, modulate splenic T helper cell, and ameliorate neuroinflammation in i.c.v. A beta 1-42 injected Alzheimer's disease (AD) mice. To explore the mechanism of action, network pharmacology was performed to predict protein targets and pathways of HET-B against AD. Five key targets were identified related to the effect of HET-B in AD intervention, and were clarified involved in axonal regeneration. We revealed for the first time that HET-B promoted memory retrieval through axonal regeneration and anti-neuroinflammation. This study provides a basis to research on HET-B as nutritional supplements for brain healthy.